Milwaukee Brewers vs St. Louis Cardinals Prediction 4/25/25 MLB Picks

St. Louis Cardinals (10-15) vs Milwaukee Brewers (13-13)

Game Info: Friday, April 25, 2025 at 8:15 pm (Busch Stadium)

C. Patrick (R) vs M. Liberatore (L)

Betting Odds: St. Louis Cardinals -130 / Milwaukee Brewers +110 --- Over/Under: 8 Click Here for the Latest Odds

Where to Watch: MLB.TV

In this article, we will formulate a Milwaukee Brewers vs St. Louis Cardinals Prediction for this MLB game on Friday, April 25th, at Busch Stadium. To formulate this prediction, we will look at: 

-The Brewers’ recent form and recent player performance

-The Cardinals’ recent form and recent player performance

-Recent Betting trends and streaks involving Milwaukee

-Recent Betting trends and streaks involving St. Louis

-Recent betting trends in games played between Milwaukee and St. Louis

-A summary that ties it all together produces a favorable betting outcome for Today’s Game between the Brewers and Cardinals. 

Disappointing Loss for the Brewers

It was a disappointing loss for the Brewers on Thursday and they ended up blowing the game late. The Brewers scored five runs in the first four innings, but they didn’t score the rest of the game, and that led to the defeat. Tyler Alexander made it 0.1 innings and gave up two earned runs. Catcher Eric Haase did have a decent game, finishing with a hit, and he also drove in an RBI. 

The Brewers are averaging 5.08 runs while their pitching is giving up 4.52 runs per game. The offense is ranked 5th while the pitching is ranked 19th. They have leaned on the offense all season, and it’s been up and down the lineup for the success. Jackson Churio has hit five home runs and driven in 20 RBIs. Getting the start for the Brewers will be Chad Patrick, who sits with a 1-1 record and an ERA of 2.11. Against the Oakland Athletics, he went six innings, giving up seven hits and two runs. 

Why the Brewers Will Beat the Cardinals

  • The Brewers have won each of their last nine games as road underdogs against NL Central opponents following a loss.
  • The Cardinals have lost each of their last six games as favorites following a road loss.
  • The Brewers have covered the run line in each of their last nine games as road underdogs against NL Central opponents following a loss.
  • The Cardinals have failed to cover the run line in each of their last six games as favorites following a road loss.

Another Series Loss for the Cardinals

It was another lost series for the St. Louis Cardinals this week against the Atlanta Braves. On Wednesday, St. Louis scored only one run, and that led to the three-run defeat. Nolan Arenado was the only offensive success, hitting a home run and driving in one RBI. The most disappointing part of the Cardinals game was they wasted a good Miles Mikolas start. He went six innings giving up six hits and zero earned runs. JoJo Romero went 0.1 innings giving up two hits and two earned runs. 

The Cardinals are averaging 4.8 runs while their pitching is giving up 4.7 runs per game. The offense is ranked 7th in the league while the pitching is ranked 23rd. Lars Nootbaar hit four home runs and driven in 14 RBIs. Getting the start for the Cardinals will be Matthew Liberatore who sits with a 1-2 record and an ERA of 3.60. Against the New York Mets he went 6.2 innings giving up six hits and two runs. 

Total Run Facts

  • Seven of the Cardinals' last eight home games against NL Central opponents have gone UNDER the total runs line.
  • Three of the Brewers' last four road games against NL Central opponents have gone UNDER the total runs line.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Cardinals' last nine games as home favorites against NL Central opponents.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Brewers' last six night games.

Milwaukee Brewers vs St. Louis Cardinals Prediction

Give me the Brewers here. The Cardinals bullpen was a problem in the last game and it could be a big problem again here. Even if Liberatore has another strong start here, it’s not going to matter, because Patrick is going to even better. He currently sits with an ERA of 2.11 and he’s going to step up in a major way here. The Cardinals will struggle to hit even two runs here, and the Brewers will get the job done. 

The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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