Chicago White Sox vs Athletics Prediction 4/25/25 MLB Picks

Athletics Betting Preview

The Athletics are 12-13 on the year and play the Rangers, Marlins, and Mariners next. The Athletics are batting .254 on the season, have a .313 OBP, and a .432 slugging percentage. The Athletics pitching staff has a 4.46 ERA and a 1.45 WHIP. Jacob Wilson leads the Athletics with 31 hits and 12 RBI while Tyler Soderstrom and Lawrence Butler have combined for 54 hits and 28 RBI.

Luis Severino gets the ball for the Athletics, and he is 1-3 with a 3.31 ERA and 22 strikeouts this season. Severino is 2-3 with a 4.43 ERA and 47 strikeouts in his career against the Chicago White Sox.

Why the Athletics will win

• The White Sox have lost 12 of their last 13 road games following a road win.
• The Athletics have won five of their last six games against American League opponents.
• The White Sox have failed to cover the run line in each of their last six night games against American League opponents following a road win.
• The Athletics have covered the run line in eight of their last nine games against American League opponents.
• The Athletics have led after 3 innings in three of their last four home games against American League opponents.
• The White Sox have trailed after 5 innings in seven of their last nine road games.

Why the Chicago White Sox will win

• The Athletics have lost each of their last four games as home favorites following a win.
• The road team has won each of the last three games between the White Sox and Athletics.
• The Athletics have failed to cover the run line in seven of their last eight games as home favorites after playing the previous day.
• The White Sox have covered the run line in four of their last five road games against AL West opponents that held a losing record.

Athletics Player Prop Facts

• Lawrence Butler has hit a home run in each of the Athletics' last three games as favorites against AL opponents.
• Gio Urshela has recorded at least one RBI in five of his last six appearances with his team as a favorite.
• Luis Severino has recorded six or more strikeouts in each of his last three appearances against opponents that held a losing record.
• Luis Severino has recorded a win in three of his last four home appearances against AL opponents that held a losing record.
• Brent Rooker has recorded at least one Single in seven of the Athletics' last eight night games against AL opponents that held a losing record.
• Lawrence Butler has scored a run in each of the Athletics' last four home games against AL opponents.
• Lawrence Butler has recorded at least one hit in each of the Athletics' last 10 night games against AL opponents that held a losing record.
• Tyler Soderstrom ranks 7th amongst qualified players for Slugging Percentage (.615) this season.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit a home run in each of the White Sox's last two road games against the Athletics.
• Andrew Benintendi has recorded at least one RBI in five of the White Sox's last six road games against AL West opponents that held a losing record.
• Andrew Benintendi has recorded a Single in each of his last six road appearances against AL opponents that held a losing record.
• Andrew Vaughn has recorded at least one hit in each of his last nine appearances with the White Sox as underdogs against the Athletics.
• Korey Lee has scored a run in each of his last three appearances against AL West opponents.

Chicago White Sox vs Athletics Prediction

The Chicago White Sox have won two games in a row just once this season and Burke isn’t somebody I’m excited to back. Through 21.2 innings, Burke has allowed 24 hits and 15 earned runs. The Athletics already tagged Burke for six hits and five runs in 3.1 innings this season. The Athletics are coming off a nice series win over the Rangers, and Severino has allowed seven hits and two runs in his last 13.2 innings. Severino hasn’t pitched well in Sacramento this year, but he’s a veteran who should figure it out sooner than later. The price is insane given these are two below-average teams. Still, give me the Athletics, and I’ll lay the RL to shave down the price.