New York Yankees vs Cleveland Guardians Prediction 4/23/25 MLB Picks

Cleveland Guardians (14-9) vs New York Yankees (14-10)

Game Info: Wednesday, April 23, 2025 at 1:10 pm (Progressive Field)

C. Rodon (L) vs L. Ortiz (R)

Betting Odds: Cleveland Guardians +124 / New York Yankees -148 --- Over/Under: 8.5 Click Here for the Latest Odds

Where to Watch: MLB.TV

In this article, we will formulate a Yankees vs Guardians prediction for this MLB game on Wednesday, April 23, at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup.

New York Yankees Betting Preview

The New York Yankees (14-10, 6-6 Away) were in fine form with six wins in seven games, during which they swept the Royals and won the series against the Rays. However, the current series in Cleveland is not going well, as the Yankees lost the opening two games and now are trying to avoid the sweep. In a 3-2 defeat in Game 2, New York had a 2-0 lead, but the Guardians responded with three runs in the 6th inning. Will Warren pitched for 5.0 innings in a no-decision, allowing two runs on three hits with five strikeouts and one walk. Mark Leiter Jr. took the loss.

This year, the Yankees average 5.65 runs per game (2nd in the MLB) on a .258/.342/.468 triple-slash. When it comes to pitching, the Yankees’ staff has a 4.10 ERA (17th) and 1.23 WHIP (14th). Aaron Judge leads the Yankees with a .411 batting average, seven home runs, and 25 RBI this season.

Carlos Rodon will take the mound for the Yankees on Wednesday. The 32-year-old left-hander has a 2-3 record in five starts this year with a 4.34 ERA and 1.10 WHIP in 29.0 innings.

Cleveland Guardians Betting Preview

The Cleveland Guardians (14-9, 7-1 Home) are on a five-game winning streak after sweeping the Pirates and defeating the Yankees in the first two games of the current series at Progressive Field. The Guardians already had a five-game winning run this year, and now will try to make it six in a row for the first time. In the latest 3-2 victory over the Yanks, Tanner Bibee got the win after allowing two runs on five hits with five strikeouts and three walks over 6.0 innings of work.

This season, the Guardians average 4.18 runs per game (20th in the MLB) on a .240/.313/.402 slash line. Regarding pitching, the Guardians’ staff has a 3.98 ERA (13th) and 1.35 WHIP (23rd). Kyle Manzardo leads the Guardians with a .219 batting average, seven home runs, and 18 RBI this season.

The projected starting pitcher for the Guardians is Luis Ortiz, who is 2-2 in four starts this season, with a 5.48 ERA and 1.41 WHIP in 21.1 innings.

Why the Yankees will beat the Guardians

  • The Yankees have won each of their last 11 Wednesday games against AL Central opponents that held a winning record.
  • The Guardians have lost each of their last six Wednesday games against AL East opponents.
  • The Yankees have covered the run line in each of their last six road games against the Guardians following a road loss.
  • The Guardians have failed to cover the run line in eight of their last nine games as underdogs against the Yankees following a home win.
  • The Guardians have trailed after 3 innings in three of their last four games against American League opponents.
  • The Yankees have led after 5 innings in four of their last five games.

Total Runs Facts

  • Five of the Yankees' last six games as favorites have gone UNDER the total runs line.
  • Three of the Guardians' last four games as underdogs against American League opponents have gone OVER the total runs line.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in eight of the Guardians' last nine games as underdogs against American League opponents.
  • The 'Inning 1 OVER 0.5 runs' market has hit in each of the Yankees' last four day games.

Matchup/League Facts

  • The Guardians rank 10th in the league for home runs this season (28).
  • The Guardians rank 21st in the league for opponent batting average this season (.249).
  • The Yankees rank 30th in the league for walks allowed this season (101).
  • The Yankees rank 1st in the league for opponent batting average this season (.202).

Yankees vs Guardians Prediction

The Yankees won six of the previous ten H2H encounters, but the Guardians were better in three of the last five. Carlos Rodon didn't experience the best of starts this season, but he had his first shutout in his previous start against the Rays. I don't say he will have another shutout here, but I am backing Rodon for a quality start. The Guardians have a .238 BA against southpaws this season, so I think they will score a maximum of two or three runs off Rodon. Luis Ortiz, on the other hand, could struggle against a strong lineup such as the Yankees'. New York hasn't suffered a series sweep yet this season, and I am backing the Yankees to salvage this series as well.

Oliver’s Pick Yankees ML

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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