Pittsburgh Pirates vs Los Angeles Angels Prediction 4/22/25 MLB Picks

-Recent Betting trends and streaks involving Pittsburgh

-Recent Betting trends and streaks involving LA

-Recent betting trends in games played between Pittsburgh and Los Angeles

-A summary that ties it all together produces a favorable betting outcome for Today’s Game between the Pirates and Angels. 

Another Slow Start for the Pirates

It’s another slow start to the season for the Pirates, and they come into this game having lost three games in a row. On Sunday, the Pirates scored four runs against the Cleveland Guardians, but it wasn’t enough as the pitching gave up five. Adam Frazier finished with one hit and two RBIs. Mitch Keller went five innings, giving up five hits and two runs. On Saturday, the Pirates' offense was not good, scoring zero runs. 

The Pirates are averaging 3.39 runs while their pitching is giving up 4.48 runs per game. The offense is ranked 26th, and it’s been the thing that has consistently let them down. Oneil Cruz has hit five home runs and driven in 11 RBIs. Getting the start for the Pirates will be Bailey Falter, who sits with a 1-2 record and an ERA of 4.91. Against the Washington Nationals, he went seven innings, giving up two hits and zero runs. They are going to need him to be dominant again. 

Why the Angels Will Beat the Pirates

• The Pirates have lost each of their last seven games as road underdogs.
• The Angels have won four of their last five games at Angel Stadium of Anaheim.
• The Pirates have failed to cover the run line in each of their last four games as underdogs.
• The Angels have covered the run line in eight of their last 10 home games against NL Central opponents that held a losing record.
• The Angels have led after 3 innings in three of their last four games as favorites against NL Central opponents.
• The Angels have led after 5 innings in three of their last four games against the Pirates at Angel Stadium of Anaheim.

Can Angels Win Another Series?

The Angels faced off against the San Francisco Giants over the weekend, and they were able to win two of the three games. On Sunday, the Angels scored five runs and ended up on top by one. Zach Neto hit a home run and drove in two RBIs, while Zach Neto also finished with three RBIs. Yusei Kikuchi was a big offseason addition, and he went 5.1 innings, giving up five hits and zero runs. 

The Angels are averaging 4.9 runs while their pitching is giving up 4.62 runs per game. The stats aren’t actually all that great for this team, but they hope they can make a run after the success over the weekend. Getting the start for the Angels will be Jose Soriano, who sits with a 2-2 record and an ERA of 3.16. Against the Texas Rangers in his last start, he went 5.2 innings, giving up 10 hits and three runs. 

Total Run Facts

• Each of the Pirates' last four games as underdogs against American League opponents have gone OVER the total runs line.
• Six of the last seven games between the Pirates and Angels at Angel Stadium of Anaheim have gone OVER the total runs line.
• The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Angels' last seven Tuesday games.
• The 'Inning 1 UNDER 0.5 runs' market has hit in six of the Pirates' last seven road games against AL West opponents.

Pittsburgh Pirates vs LA Angels Prediction

The Angels are coming off a series win, and they are going to continue that success here. Sorano sits with an ERA of 3.16, and he’s going to have a huge game here. The Pirates' offense is ranked 26th in all of baseball, and they are going to really struggle to get any sort of offense going here. Soriano gave up 10 hits in his last start, but he won’t even get close to that number here. Back the Angels on the money line.