Seattle Mariners vs Cincinnati Reds Prediction 4/16/25 MLB Picks

Cincinnati Reds (9-8) vs Seattle Mariners (8-9)

Game Info: Wednesday, April 16, 2025 at 6:40 pm (Great American Ball Park)

B. Miller (R) vs N. Martinez (R)

Betting Odds: Cincinnati Reds +102 / Seattle Mariners -122 --- Over/Under: 8.5 Click Here for the Latest Odds

Where to Watch: FS1

In this article, we will formulate a Mariners vs Reds prediction for this MLB game on Wednesday, April 16, at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Betting Preview

The Seattle Mariners (8-9, 0-4 Away) displayed some weak performances in the opening three series of the season, as they failed to win any. The Mariners then bounced back with a win over the Astros and a series sweep against the Rangers. They were on a four-game winning streak but lost Game 1 of the current series against the Reds. Dylan Moore was excellent on offense with two homers and four RBI in an 8-4 loss, while Luis Castillo took the loss after allowing six runs on seven hits with three strikeouts and four walks in 4.1 innings.

This year, the Mariners average 3.81 runs per game (23rd in the MLB) on a .210/.308/.359 triple-slash. When it comes to pitching, the Mariners’ staff has a 3.54 ERA (8th) and 1.28 WHIP (18th). Jorge Polanco leads the Mariners with a .378 batting average, three home runs, and 12 RBI this season.

Bryce Miller will take the mound for the Mariners on Wednesday. The 26-year-old right-hander has a 0-2 record in three starts this season with a 4.50 ERA and 1.44 WHIP in 16.0 innings.

Cincinnati Reds Betting Preview

The Cincinnati Reds (9-8, 6-4 Home) also experienced a slow start to the season but are playing much better at the moment. The Reds won six of the previous seven games and are on a four-game winning run after sweeping the Pirates and defeating the Mariners in the opening game of the current series. Austin Hays led Cincinnati with four RBI in an 8-4 victory, while Nick Lodolo pitched for 4.2 innings in a no-decision, allowing four runs on five hits with six strikeouts and one walk. Scott Barlow was credited with the win.

This season, the Reds average 3.88 runs per game (22nd in the MLB) on a .200/.272/.320 slash line. Regarding pitching, the Reds’ staff has a 2.87 ERA (3rd) and 0.92 WHIP (1st). Elly De La Cruz leads the Reds with a .224 batting average, three home runs, and 18 RBI this season.

The projected starting pitcher for the Reds is Nick Martinez, who is 0-2 in three starts this season, with a 6.06 ERA and 1.22 WHIP in 16.1 innings.

Total Runs Facts

  • Six of the Reds' last seven night games after playing the previous day have gone UNDER the total runs line.
  • Four of the Mariners' last five games have gone OVER the total runs line.
  • The 'Inning 1 OVER 0.5 runs' market has hit in each of the Reds' last six night games against AL West opponents.
  • The 'Inning 1 OVER 0.5 runs' market has hit in each of the Mariners' last four games.

Matchup/League Facts

  • The Reds rank 29th in the league for hits this season (110).
  • The Reds rank 2nd in the league for walks allowed this season (42).
  • The Mariners rank T27th in the league for hits this season (113).
  • The Mariners rank 27th in the league for batting average this season (.208).

Mariners vs Reds Prediction

The Mariners won six of the previous ten H2H encounters, including four of the last five. Bryce Miller allowed a .310 BA in 29 at-bats against the Reds, while Nick Martinez allowed a .323 BA in 31 at-bats against the Mariners. I think both pitchers will surrender multiple runs in the opening four or five innings, and that's why I am going with Over in this one. Six of Seattle's last ten games went over, and three of the previous four on the road. The teams combined for 12 runs in Game 1, and I expect at least nine on Wednesday.

The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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