Houston Astros vs St. Louis Cardinals Prediction 4/15/25 MLB Picks

Astros Still Struggling To Be Consistent

Jose Altuve leads the Astros with 19 hits, including 3 home runs and 7 RBIs. Jeremy Pena also has a pair of homers and 4 stolen bases, while Yordan Alvarez has 2 doubles and a team-high 9 RBIs with 17 strikeouts as well. Brendan Rodgers has a pair of doubles, while Jake Meyers has a pair of doubles as well, and Christian Walker has also accrued a team-high 20 strikeouts so far this season. Altuve also has 3 stolen bases, while Jake Meyers has a team-high 5 stolen bases this season.

Why the Houston Astros will win

• The Astros have won each of their last six games following a road loss.
• The Cardinals have lost five of their last six night games against American League opponents following a win.
• The Astros have covered the run line in each of their last six games following a road loss.
• The Cardinals have failed to cover the run line in six of their last seven night games against AL West opponents following a win.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in three of the Astros' last four games as favorites.
• Yainer Diaz has recorded at least one RBI in four of the Astros' last five games as favorites against the Cardinals.
• Jeremy Pena has scored at least one run in each of the Astros' last four games as road favorites.
• Jose Altuve has recorded at least one Single in 10 of the Astros' last 11 games as favorites against NL opponents.
• Jeremy Pena has recorded at least one hit in each of the Astros' last seven games against the Cardinals.
• Jake Meyers ranks T10th in the league in Steals (5) this season.

St. Louis Cardinals Recap

The St. Louis Cardinals will try to keep the ball rolling after picking up the W in Monday’s series opener to get back to 8-8 on the year. After this series, the Cardinals will head on the road for a series against the New York Mets.

Cardinals Win Back-To-Back Games

Brendan Donovan has a team-high 21 hits, along with 4 doubles, 2 home runs, and 10 RBIs, while Lars Nootbaar has 15 hits with a pair of home runs and a pair of stolen bases. Noaln Arenado also has 15 hits with 4 doubles of his own, and Victor Scott II has 14 hits with a pair of doubles, a triple, 7 RBIs, and a team-high 5 stolen bases. Ivan Herrera has also added a team-high 4 home runs and 11 RBIs so far this season.

Why the St. Louis Cardinals will win

• The Astros have lost each of their last seven games as road favorites against NL Central opponents.
• The Cardinals have won eight of their last nine games as home underdogs.
• The Astros have failed to cover the run line in each of their last eight games against NL Central opponents.
• The Cardinals have covered the run line in 10 of their last 11 games as underdogs after playing the previous day.

St. Louis Cardinals Player Prop Facts

• Nolan Arenado has hit a home run in three of his last four home appearances against the Astros after playing the previous day.
• Nolan Arenado has recorded at least one Double in each of the Cardinals' last four games against AL opponents that held a losing record.
• Nolan Arenado has scored at least one run in each of his last seven home appearances against AL opponents that held a losing record.
• Nolan Arenado has recorded at least one RBI in seven of the Cardinals' last eight home games against AL opponents.
• Brendan Donovan has recorded at least one Single in each of the Cardinals' last 11 games against opponents that held a losing record.
• Erick Fedde has recorded four or more strikeouts in five of his last six appearances against AL West opponents.
• Brendan Donovan has recorded at least one hit in each of the Cardinals' last 14 games as underdogs.
• Brendan Donovan ranks 1st in the league in Hits (25) this season.

Total Runs Facts

• Each of the Cardinals' last six night games after playing the previous day have gone OVER the total runs line.
• Six of the Astros' last seven night games against NL Central opponents have gone OVER the total runs line.

Houston Astros vs. St. Louis Cardinals Prediction

I’m on the under here. I think Erick Fedde’s lack of strikeouts will come back to bite him down the road, but not in this start with an Astros lineup that looks like a shell of what they’ve been in past seasons. On the other side, Hunter Brown is still one of Houston’s best arms and has staff ace stuff, and it wouldn’t surprise me if he ended up being Houston’s ace in a couple of years. I think he holds down the Cardinals lineup in a low-scoring battle here, so give me the under.