Chicago Cubs vs San Diego Padres Prediction 4/15/25 MLB Picks

The Chicago Cubs and San Diego Padres meet on Tuesday in MLB action at Petco Park. Here’s a Chicago Cubs vs San Diego Padres Prediction. This article will include a Chicago Cubs vs San Diego Padres Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 11-8 on the year and play the Diamondbacks, Dodgers, and Phillies next. The Chicago Cubs are batting .258 on the season, have a .347 OBP, and a .441 slugging percentage. The Chicago Cubs pitching staff has a 4.37 ERA and a 1.39 WHIP. Kyle Tucker leads the Chicago Cubs with 23 hits and 18 RBI, while Pete Crow-Armstrong and Seiya Suzuki have combined for 38 hits and 23 RBI. 

Shota Imanaga gets the ball for the Chicago Cubs, and he is 2-1 with a 2.70 ERA and 14 strikeouts this season. Imanaga is 1-0 with a 1.88 ERA and 12 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 14-3 on the year and play the Astros, Tigers, and Rays next. The San Diego Padres are batting .284 on the season, have a .352 OBP, and a .433 slugging percentage. The San Diego Padres pitching staff has a 2.70 ERA and a 1.07 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 22 hits and 12 RBI, while Luis Arraez and Manny Machado have combined for 40 hits and 11 RBI.

Randy Vasquez gets the ball for the San Diego Padres, and he is 1-1 with a 1.72 ERA and 6 strikeouts this season. Vasquez is 0-1 with a 3.00 ERA and 8 strikeouts in his career against the Chicago Cubs.

Why the San Diego Padres will win

• The Padres have won each of their last 11 home games.
• The Cubs have lost seven of their last nine games as road favorites against NL West opponents following a loss.
• The Padres have covered the run line in each of their last nine home games.
• The Cubs have failed to cover the run line in four of their last five night games against National League opponents that held a winning record.
• The Cubs have trailed after 3 innings in four of their last five games at Petco Park against NL West opponents that held a winning record.

Why the Chicago Cubs will win

• The Cubs have won each of their last seven road games against the Padres following a loss.
• The Padres have lost seven of their last eight games against the Cubs following a win.
• The Cubs have covered the run line in each of their last seven road games against the Padres following a loss.
• The Padres have failed to cover the run line in seven of their last eight games against the Cubs at Petco Park following a win.
• The Cubs have led after 5 innings in nine of their last 10 games as road favorites.

Chicago Cubs vs San Diego Padres Prediction

The Cubs are favored because Imanaga is on the mound, one of the best young pitchers in baseball. However, the value is with the Padres and the plus money. Despite 12 walks through 15.2 innings, Vasquez has allowed seven hits and three earned runs. Also, the Padres have won five straight games and have an 82.4 percent winning percentage on the season. As long as this run continues, it’s not only tough to bet against the Padres, but it’s impossible to turn down plus money when you can get it. With a 14-3 record, no team has earned MLB bettors more money than the Padres up to this point. Give me the home dog.