Chicago White Sox vs Cleveland Guardians Prediction 4/9/25 MLB Picks

Cleveland Guardians (4-6) vs Chicago White Sox (2-8)

Game Info: Wednesday, April 9, 2025 at 6:10 pm (Progressive Field)

S. Burke (R) vs L. Allen (L)

Betting Odds: Cleveland Guardians -192 / Chicago White Sox +160 --- Over/Under: 7.5 Click Here for the Latest Odds

Where to Watch: MLB.TV

In this article, we will formulate a White Sox vs Guardians prediction for this MLB game on Wednesday, April 9, at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Betting Preview

The Chicago White Sox (2-8, 0-4 Away) are currently on a six-game losing skid after falling short 1-0 to the Guardians in the opening game of this series. Prior to it, the White Sox lost to the Angels and Twins and suffered a three-game series sweep against the Tigers. In the latest 1-0 loss in Cleveland, the White Sox had just two hits. Shane Smith pitched for 6.0 innings in a no-decision, allowing no runs on two hits with six strikeouts and one walk, while Mike Clevinger took a loss.

This season, the White Sox average 3.56 runs per game (23rd in the MLB) on a .211/.273/.344 slash line. Regarding pitching, the White Sox’ staff has a 4.02 ERA (14th) and 1.29 WHIP (15th). Andrew Benintendi leads the White Sox with a .290 batting average, two home runs, and six RBI this season.

The projected starting pitcher for the White Sox is Sean Burke, who has a 1-1 record in two starts this year with a 5.23 ERA and 0.97 WHIP in 10.1 innings.

Cleveland Guardians Betting Preview

The Cleveland Guardians (4-6, 1-0 Home) have one series win this season, and it was in the opening series against the Royals on the road. After that, the Guardians were swept by the Padres and lost to the Angels before defeating the White Sox in Game 1 of the current series. Nolan Jones scored a game-winning RBI in the 9th inning, while Ben Lively pitched for 5.0 innings in a no-decision, allowing no runs on two hits with four strikeouts and three walks. Emmanuel Clase was credited with a win.

This year, the Guardians average 3.78 runs per game (17th in the MLB) on a .221/.300/.400 triple-slash. When it comes to pitching, the Guardians’ staff has a 5.09 ERA (27th) and 1.54 WHIP (28th). Kyle Manzardo leads the Guardians with a .242 batting average, three home runs, and nine RBI this season.

Logan Allen will take the mound for the Guardians on Wednesday. The 26-year-old lefty has a 0-1 record in one start this year with a 6.75 ERA and 2.25 WHIP over 5.1 innings of work.

Total Runs Facts

  • Five of the Guardians' last six night games against American League opponents have gone OVER the total runs line.
  • Three of the White Sox's last four night games against AL Central opponents have gone UNDER the total runs line.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in 10 of the White Sox's last 11 night games.
  • The 'Inning 1 OVER 0.5 runs' market has hit in each of the last four night games between the White Sox and Guardians at Progressive Field.

Matchup/League Facts

  • The Guardians rank T28th in the league for steals this season (3).
  • The Guardians rank T27th in the league for doubles this season (11).
  • The White Sox rank 2nd in the league for strikeouts against this season (75).
  • The White Sox rank 28th in the league for on-base percentage this season (.268).

White Sox vs Guardians Prediction

The Guardians won seven of the previous ten H2H encounters, including the last five. Five of the past seven H2Hs produced 8+ runs, and given how these starters play early in the season, I expect another Over. Logan Allen posted a 4.50 ERA in two starts against the White Sox last year and allowed a .407 BA in 54 at-bats against Chicago in his career. The White Sox could find success against him on Wednesday, especially Andrew Vaughn and Luis Robert Jr. I expect a response from the White Sox after failing to score on Tuesday. I am going with Over. 

The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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