San Francisco Giants vs Cincinnati Reds Prediction 3/29/25 MLB Picks

Cincinnati Reds (0-1) vs San Francisco Giants (1-0)

Game Info: Saturday, March 29, 2025 at 4:10 pm (Great American Ball Park)

J. Verlander (R) vs N. Lodolo (L)

Betting Odds: Cincinnati Reds -125 / San Francisco Giants +105 --- Over/Under: 8.5 Click Here for the Latest Odds

Where to Watch: NBC Sports BA

In this article, we will formulate a San Francisco Giants vs Cincinnati Reds prediction for this MLB game on Saturday, March 29th, at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

San Francisco Giants Betting Preview

The San Francisco Giants are 1-0 this year after they defeated Cincinnati by a score of 6-4 on Thursday. San Francisco trailed 3-0 after the third inning, but they were able to score the next six runs and secure the win. The Giants scored two runs in the fourth and four in the ninth, and they totaled six hits in the process. Ramos went 1-4 with one home run and two RBIs in the game, while Flores went 1-4 with one home run and three RBIs. Logan Webb started for the Giants, but he allowed six hits and three earned runs over 5.0 innings of work. Rodriguez, Miller, and Rogers all pitched scoreless innings in relief, while Walker allowed one earned run in the ninth but did get the save. 

Last season, the San Francisco pitching staff had a 4.10 ERA with a 1.30 WHIP and a .246 opponent batting average, while the offense scored 693 runs with a .239 batting average and a .305 on-base percentage. The Giants were right in the middle of the pack in team ERA and runs scored last season, but they need to really improve if they want to compete in the NL West. The Giants were led by Matt Chapman, who hit .247 with 27 home runs and 78 RBIs last year. The projected starting pitcher for San Francisco is Justin Verlander, who was 5-6 with a 5.48 ERA and a 1.38 WHIP over 90.1 innings pitched for the Astros last year. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 0-1 this season after they lost to San Francisco by a score of 6-4 in their first game. Cincinnati took an early 3-0 lead on two different RBI singles from Candelario, but they allowed the next six runs in the game for the loss. The Reds did get one run back in the ninth but fell short in the comeback attempt. Candelario went 2-3 with three RBIs in the game, while Friedl went 2-5 with one RBI. Hunter Greene was the starting pitcher for Cincinnati, and he allowed three hits and two earned runs over 5.0 innings. Barlow, Pagan, and Santillan threw scoreless innings out of the bullpen, but Gibaut allowed four earned runs in 0.2 innings for the loss. The Reds will meet the Rangers after this series.

Last year, the Cincinnati pitching staff had a 4.09 ERA with a 1.25 WHIP and a .239 opponent batting average, while their offense scored 699 runs with a .231 batting average and a .305 on-base percentage. Cincinnati was also in the middle of the MLB in team ERA and runs scored, and they also need big improvement to compete with the Brewers. The Reds were led by Elly De La Cruz, who hit .259 with 25 home runs and 76 RBIs last year. The projected starting pitcher for Cincinnati is Nick Lodolo, who was 9-6 with a 4.76 ERA and a 1.20 WHIP over 115.1 innings pitched in 2024.

Why the Reds will beat the Giants 

  • The Reds have won each of their last eight games at Great American Ball Park against NL West opponents that held a winning record.
  • The Giants have lost each of their last four games against NL Central opponents following a road win.
  • The Reds have covered the run line each of their last seven games at Great American Ball Park against NL West opponents that held a winning record.
  • The Giants have failed to cover the run line in four of their last five day games against teams that held a losing record.
  • The Reds have led after 5 innings in each of their last three games against NL West opponents that held a winning record.
  • The Giants have trailed after 3 innings in six of their last seven day games against NL Central opponents.

Total Runs Facts

  • Each of the Reds' last five games as favorites against NL West opponents have gone OVER the total runs line.
  • Five of the Giants' last six games against National League opponents have gone OVER the total runs line.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Reds' last six games as home favorites against NL West opponents.
  • The 'Inning 1 UNDER 0.5 runs' market has hit in each of the Giants' last five games as road underdogs against NL Central opponents.

Cincinnati Reds Player Prop Facts

  • Spencer Steer has scored at least one run in each of the Reds' last four games at Great American Ball Park against NL West opponents that held a winning record.
  • Gavin Lux has recorded at least one Single in five of his last six appearances with his team as a favorite against NL West opponents.
  • Santiago Espinal has recorded an RBI in each of his last five appearances with the Reds as home favorites against NL West opponents.
  • Gavin Lux has recorded at least one hit in each of his last nine Saturday day appearances with his team as a favorite.
  • Tyler Stephenson has hit at least one home run in four of the Reds' last five games as home favorites against NL West opponents.

San Francisco Giants Player Prop Facts

  • Willy Adames has recorded at least one RBI in each of his last four appearances at Great American Ball Park against opponents that held a losing record.
  • Mike Yastrzemski has recorded a hit in each of his last eight appearances in day games against NL teams that held a losing record.
  • Willy Adames has hit a home run in each of his last four appearances at Great American Ball Park against NL Central opponents that held a losing record.
  • Matt Chapman has scored at least one run in each of the Giants' last six day games against NL Central opponents that held a losing record.
  • Matt Chapman has recorded a Single in each of the Giants' last five games against NL opponents that held a losing record.

San Francisco Giants vs Cincinnati Reds Prediction 

The Giants were able to have a huge ninth inning to steal the win in game one of this series on Thursday, but they will be going against Lodolo, who is going to have a solid season, in my opinion. Neither offense is very high-scoring, but I can’t trust Verlander on the mound. JV has had a fantastic career, but he is 42 years old now and had a rough season in Houston last year. Give me the Reds to get the win here. 

David’s Pick Reds ML

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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