Chicago Cubs vs Arizona Diamondbacks Prediction 3/29/25 MLB Picks

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks will play the Yankees, Nationals, and Orioles next. The Diamondbacks bounced back on Friday with an 8-1 win, and the offense is living up to the hype with 14 runs scored through two games. The Diamondbacks will be in every game this season due to their ability to put runs on the board. The Diamondbacks will wrap up this series this weekend before leaving out east for a six-game road trip. Ketel Marte leads the Diamondbacks with 4 hits, while Eugenio Suarez and Pavin Smith have combined for 6 hits and 6 RBI.

Brandon Pfaadt gets the ball for the Diamondbacks, and he was 11-10 with a 4.71 ERA and 185 strikeouts last season. Pfaadt is 1-1 with a 2.13 ERA and 23 strikeouts in his career against the Cubs.

Why the Arizona Diamondbacks will win

• The Cubs have lost each of their last seven Saturday night games against NL West opponents.
• The favorites have won seven of the Cubs' last eight games.
• The Cubs have failed to cover the run line in six of their last seven night games against NL West opponents.
• The Diamondbacks have covered the run line in five of their last six games against NL Central opponents.
• The Diamondbacks have led after 5 innings in three of their last four games against NL Central opponents.
• The Cubs have lost the first inning in three of their last four road games.

Why the Chicago Cubs will win

• The Diamondbacks have lost each of their last five games as favorites against the Cubs following a home win.
• The Cubs have won each of their last four games as underdogs against the Diamondbacks following a road loss.
• The Cubs have covered the run line in each of their last seven games as underdogs against National League opponents following a road loss.
• The Diamondbacks have failed to cover the run line in each of their last six games as favorites against the Cubs following a home win.

Chicago Cubs vs Arizona Diamondbacks Prediction

The Diamondbacks are the sexy, trendy pick this season, and for good reason, as their lineup is arguably the best in baseball. However, the Cubs and the plus money have to be the play in this spot. We’re getting the more favorable price with one of the best young pitchers in Shota Imanaga, who has also had a chance to get the jitters out of the way with a game under his belt this season. Brandon Pfaadt was hittable last year, and he wasn’t great in spring, allowing 18 hits and 8 runs through 15 innings. Yes, the Cubs have had their struggles overall so far, but if I can get the better starter at the better price, I’ll take it more times than not. Give me the Cubs.