Atlanta Braves vs San Diego Padres Prediction 3/28/25 MLB Picks

San Diego Padres (1-0) vs Atlanta Braves (0-1)

Game Info: Friday, March 28, 2025 at 9:40 pm (Petco Park)

Reynaldo Lopez (R) vs Dylan Cease (R)

Betting Odds: San Diego Padres -125 / Atlanta Braves +105 --- Over/Under: 7.5 Click Here for the Latest Odds

Where to Watch: FanDuel SN South

The Atlanta Braves and San Diego Padres meet on Friday in MLB action at the Petco Park. Here’s an Atlanta Braves vs San Diego Padres Prediction. This article will include an Atlanta Braves vs San Diego Padres Pick.

Atlanta Braves Betting Preview

The Atlanta Braves will play the Dodgers and Marlins after this series. The Braves lost a back-and-forth season opener due to Hector Neris allowing three runs without getting a single out. The Braves pitching staff as a whole could’ve been sharper, while the batting order struck out 10 times in 35 at-bats. The Braves also left 10 guys on base and were 0-7 with runners in scoring position, which isn’t an ideal winning formula. The Braves now hope to avoid their first 0-2 start since the 2021 season. Austin Riley leads the Braves with one hit and one RBI, while Michael Harris II and Jurickson Profar have combined for two hits and four strikeouts. 

Reynaldo Lopez gets the ball for the Braves, and he was 8-5 with a 1.99 ERA and 148 strikeouts last season. Lopez is 0-1 with a 3.38 ERA and 7 strikeouts in his career against the Padres.

San Diego Padres Betting Preview

The San Diego Padres follow up this series with games against the Guardians and Cubs. The Padres exploded for seven runs in the seventh inning to steal an opening day win. The Padres' bullpen also showed up after Michael King pitched just 2.2 innings. It was an all-around team win, and gritty performances like that are what you want to see from the Padres, who have looked soft at times over the years. The Padres hope to start 2-0 for the first time since the 2021 season. Fernando Tatis Jr. leads the Padres with three hits, while Manny Machado and Elias Diaz have combined for four hits and one RBI.

Dylan Cease gets the ball for the Padres, and he was 14-11 with a 3.47 ERA and 224 strikeouts last season. Cease is 2-0 with a 3.60 ERA and 22 strikeouts in his career against the Braves.

Why the San Diego Padres will win

  • The Padres have won eight of their last nine games at Petco Park.
  • The Braves have lost each of their last four games against NL West opponents that held a winning record.
  • The Padres have covered the run line each of their last four night games against NL East opponents that held a losing record.
  • The Braves have failed to cover the run line in three of their last four night games against NL West opponents.
  • The Padres have led after 3 innings in eight of their last 10 night games against opponents that held a losing record.
  • The Braves have lost the first inning in three of their last four games at Petco Park.
  • The Braves have trailed after 5 innings in each of their last three games against NL West opponents that held a winning record.

Why the Atlanta Braves will win

  • The Padres have lost three of their last four games as home favorites against National League opponents following a home win.
  • The Braves have won seven of their last 10 games as road underdogs following a loss.
  • The Braves have covered the run line in each of their last six games as road underdogs following a loss.
  • The Padres have failed to cover the run line in eight of their last nine night games at Petco Park following a home win.
  • The Braves have led after 5 innings in 12 of their last 16 games against National League opponents.

Atlanta Braves vs San Diego Padres Prediction

The Padres looked sharp in their season opener, and Cease is a respectable pitcher, so I wouldn’t talk you off the ledge if you're looking at the home team and the cheap price. However, we’re getting plus money with a good Braves team and an all-star in Lopez. Last season, through 135.2 innings, Lopez had an ERA of 1.99 and a WHIP of 1.1. Lopez finished 11th in NL Cy Young Voting. Maybe Lopez will come back to earth a little bit this season, but I’m going to grab the more favorable price with a guy who was one of the best pitchers in baseball last season. Give me the Braves.

Randy’s Pick Atlanta Braves +105

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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