USC vs Indiana Prediction 11/14/2026 Today’s College Football Picks

USC vs Indiana Prediction

I’m going to try USC in this one. The Trojans have had an extra week to rest and prepare for this one (but then again so have the Hoosiers), and Indiana has been involved in some close escapes lately. USC last played Ohio State on Halloween, posting a 30-18 win despite a fairly tepid offensive outing. The Trojans got 338 yards total but also just 15 first downs and a 4-of-10 success rate on third-down tries. USC’s defense surrendered 464 yards and 25 first downs, but the Buckeyes’ 11 penalties for 71 yards certainly didn’t hurt. It’s going to take a real push on both sides of the ball if USC wants to be competitive here, but I think they can pull it off.

As for Indiana, they’ve been giving their fans heart attacks lately. The Hoosiers are coming off yet another tight one, a seven-point overtime win against Minnesota. In that one Indiana held the Gophers to just 10 first downs, 215 total yards and 3-of-15 on third downs. The offense gained 419 yards on the other side but also went just 2-of-13 on thirds and had two turnovers. Indiana has been involved in four straight games decided by seven points or fewer, but they’ve been able to win three of those. This one could be close as well if USC plays to their capabilities.

Game Info, Stats and Previews

The USC Trojans and the Indiana Hoosiers meet Saturday in college football action from Memorial Stadium in Bloomington. Here’s a collection of relevant information and reasoning for a sound USC vs Indiana prediction. We have looked at this information from a betting perspective and attempted to determine the best USC vs Indiana pick. We will also examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. We will tie it all together to the pick summary, resulting in a sensible prediction for a favorable betting outcome in this game.

USC Trojans Betting Preview

This year the Trojans kicked things off with a win streak, taking out San Jose State, Fresno State, Louisiana and Rutgers in their first four. Since then it’s been a 3-2 run for USC. During that time they’ve beaten Washington, Penn State and Ohio State alongside losses to Oregon and Wisconsin. Over the first nine games of the year that gives the Trojans a 7-2 run.

Back on Halloween in their last outing versus Ohio State, the Trojans traded field goals during the second quarter on the way to a 20-9 halftime lead. USC would post another 10 points in the second half, powering out a 30-18 win in the end. QB Jayden Maiava was 15-of-22 for 222 yards and a TD, while King Miller led the rush on 13 carries for 78 yards and a score. Trent Mosley caught five balls for 101 yards and a TD as well.

Indiana Hoosiers Betting Preview

Over on the Indiana side, they jumped out to a 6-0 record with wins over North Texas, Howard, Western Kentucky, Northwestern, Rutgers and Nebraska. After a loss to Ohio State, the Hoosiers put up overtime wins versus Michigan and Minnesota in the next pair. Through the first nine games that gives Indiana an 8-1 record in the books for their troubles.

Matched up against Minnesota on Halloween, the Hoosiers were trailing 10-7 by the break. Indiana got a field goal in the third quarter then another to send the game to overtime. In the end the Hoosiers won it 23-16. QB Grant Wilson was 9-of-17 for 156 yards and a score, while Charlie Becker caught eight balls for 149 yards and a TD.

USC Trojans @ Indiana Hoosiers Betting Trends: Week 11

Why the Indiana Hoosiers will win

• Indiana has won 20 of its last 21 games as a top-15 AP-ranked team.
• USC has lost seven of its last eight games in Indiana.
• USC has failed to cover the spread in seven of its last eight road games as a top-15 AP-ranked team.
• USC has lost the first half in each of its last five games as an underdog in Indiana.

Why the USC Trojans will win

• Indiana has lost each of its last five November games against AP-ranked teams.
• USC has won six of its last seven November road games as an AP-ranked team.
• Indiana has failed to cover the spread in nine of its last 10 games.
• The underdog has covered the spread in six of USC’s last seven games.
• The road team has won the first half in four of Indiana’s last five games.

Total Points Facts

• Each of USC’s last four games have gone UNDER the total points line.
• Each of Indiana’s last four games against conference opponents have gone UNDER the total points line.

Indiana Hoosiers Player Prop Facts

• Heading into Week 11, Tobi Osunsanmi is the only player to record at least one sack in eight or more consecutive appearances this season.

USC Trojans Player Prop Facts

• Heading into Week 11, Trent Mosley leads USC for touchdowns (6) this season.

Matchup/League Facts

• Indiana ranks 1st among FBS teams for H1 opponent points per game this season (4.0).
• Indiana has played in the equal-highest number of games that went to overtime this season (2).
• USC ranks 14th among FBS teams for average point differential in second quarters this season (+6.8).
• USC ranks 15th among FBS teams for 3rd down conversion percentage this season (49.5).

Andrew Jett's Pick: USC Trojans +7.5