West Virginia vs Clemson Prediction 11/21/2025 Today’s College Basketball Picks

In this article we will formulate a West Virginia vs Clemson prediction for this College Basketball game on Friday, November 21st at TD Arena in Charleston, South Carolina. Let’s take a look at the prediction for this College Basketball matchup.

West Virginia Mountaineers Betting Preview

The West Virginia Mountaineers are 5-0 this season after they defeated Lafayette by a score of 81-59 in their last game. West Virginia led 36-25 at halftime and added 45 points in the second half in the win. The Mountaineers shot 50% from the field, 45% on three pointers, and 67% on free throws in the game. DJ Thomas led WVU with 25 points and three rebounds, while Honor Huff added 24 points and one rebound in the win. 

Prior to that game, West Virginia defeated Pittsburgh by a score of 71-49 and Lehigh by a score of 69-47. The Mountaineers have scored 72.8 points per game with 34.6 rebounds and 13.0 assists per game, while they have allowed 54.8 points against per game this season. Honor Huff is averaging 17.2 points and 2.0 rebounds per game, while Brenen Lorient is averaging 12.8 points and 7.4 rebounds per game for the Mountaineers. West Virginia is shooting 44.8% from the field, 69.0% on free throws, and 34.7% on three pointers this season. 

Clemson Tigers Betting Preview

The Clemson Tigers are 4-1 this year after they defeated North Alabama by a score of 81-61 in their last game. Clemson led 45-22 at halftime, but was out scored 39-36 in the second half in the win. The Tigers shot 44% from the field, 31% on three pointers, and 80% on free throws in the game. RJ Godfrey led Clemson with 16 points and six rebounds, while Zac Foster added 14 points and six assists in the win. 

Prior to that game, Clemson lost to Georgetown by a score of 79-74, but did beat Morehead State by a score of 83-56 before that. The Tigers have scored 84.6 points per game with 42.8 rebounds and 17.8 assists per game, while they have allowed 58.6 points against per game this season. Carter Welling is averaging 11.4 points and 6.4 rebounds per game, while Ace Buckner is averaging 11.0 points and 4.0 rebounds per game for the Tigers. Clemson is shooting 46.0% from the field, 73.1% on free throws, and 32.2% on three pointers this year. 

Why the West Virginia Mountaineers will win

• West Virginia has won each of its last seven night games against non-Conference opponents.
• Clemson has lost three of its last four games against non-Conference opponents at TD Arena.
• Clemson has lost the first half in three of its last four games against non-Conference opponents at neutral venues.

Total Points Facts

• Ten of Clemson’s last 11 games against non-Conference opponents have produced a total of 136+ points.
• Fourteen of West Virginia’s last 16 night games at a neutral venue have produced a total of 138+ points.

West Virginia vs Clemson Prediction 

Clemson was able to bounce back from that loss to Georgetown with a win over North Alabama, but they didn’t play a great second half in that one. The Tigers are shooting 46% from the field this year and they are averaging nearly 43 rebounds per game. West Virginia is 5-0 to start this season and they beat Pittsburgh by 22 points. The Mountaineers are shooting 45% from the field, but their defense has been very good, as they have allowed 65 points or fewer in all five games. I think West Virginia looks like a very solid team, while I have some concerns about Clemson recently. Take the points with WVU here.

David Racey's Pick: West Virginia +3.5