Villanova vs DePaul Prediction 3/4/2026 Today’s College Basketball Picks

In this article, we will formulate a Villanova vs DePaul Prediction for this college basketball matchup on Wednesday, March 4th. Let’s take a look at the prediction for this college basketball matchup.

DePaul Blue Demons Preview

The DePaul Blue Demons have a 16-13 overall record and an 8-10 record in the Big East. They are coming off a 62-51 road win against Marquette and their previous three games were a 72-71 road win against Creighton, a 71-68 home loss against Providence and a 69-57 road win against Seton Hall.

Offensively, DePaul averages 71.2 points per game, while allowing 69.2 points per game defensively. The Blue Demons shoot with 44% from the field and grab 33.4 rebounds per game, while dishing out 15.2 assists per game. They average 3.4 blocks per game and 7 steals per game defensively.

CJ Gunn leads DePaul in scoring, with an average of 13.6 points per game, while shooting with 41.4% from the field and 74.3% from the free throw line. NJ Benson is the team’s leading rebounder with 7.6 per game. Layden Blocker leads the team in assists with 3.5 per game.

Villanova Wildcats Preview

The Villanova Wildcats have a 22-7 overall record and a 13-5 record in the Big East. They are coming off an 89-57 road loss against St. John’s and their previous three games were an 82-73 home win against Butler, a 73-63 home loss against Connecticut and a 92-89 road win against Xavier.

Offensively, Villanova averages 77.2 points per game, while allowing 70.8 points per game defensively. The Wildcats shoot with 46% from the field and grab 34.6 rebounds per game, while dishing out 15.3 assists per game. They average 2.2 blocks per game and 7.5 steals per game defensively.

Tyler Perkins leads Villanova in scoring, with an average of 13.3 points per game, while shooting with 43.7% from the field and 75.3% from the free throw line. Duke Brennan is the team’s leading rebounder with 10.3 per game. Acaden Lewis leads the team in assists with 5.1 per game.

Villanova Wildcats @ DePaul Blue Demons Betting Trends: March 4, 2026

Why the DePaul Blue Demons will win

• DePaul has won nine of its last 10 games at Wintrust Arena against non-AP-ranked opponents.

Why the Villanova Wildcats will win

• Villanova has won each of its last eight games against non-AP-ranked opponents.
• DePaul has lost 19 of its last 22 home night games against Conference opponents.
• DePaul has lost the first half in each of its last nine home night games against Conference opponents.

Total Points Facts

• Each of Villanova’s last eight road games have produced a total of 142+ points.
• Seven of DePaul’s last eight night games against non-AP-ranked opponents at Wintrust Arena have produced a total of 139+ points.

Villanova vs DePaul Prediction

In this Villanova vs DePaul Prediction, Villanova is coming as -3.5 road favorites. Villanova has been the better team this season but has lost two of its last three games and has failed to cover the spread in its last four. On the flip side, DePaul is 4-1 both straight up and against the spread in its last 5 games and has a better defense than Villanova this season, so I like them as home dogs in this spot. Take DePaul and get the +3.5 points in this one.

Nikos Lagouretos's Pick: DePaul +3.5