Dec 2, 2025; Eugene, Oregon, USA; Southern California Trojans forward Chad Baker-Mazara (4) makes a three point basket late in the second half against the Oregon Ducks at Matthew Knight Arena. Mandatory Credit: Craig Strobeck-Imagn Images
Craig Strobeck-Imagn Images

UTSA vs USC Prediction 12/17/2025 Today’s College Basketball Picks

Pick details

MATCHUP UTSA Roadrunners USC Trojans
Team Records 4-6 10-1
Spread +23.5 -108 -23.5 -112
Moneyline +2000 -6500
Total Over 157.5 (-108) Under 157.5 (-112)
Where Galen Center, Los Angeles, CA
When Wednesday, December 17, 2025
Time 09:00 PM EST
TV BTN

The UTSA Roadrunners and the USC Trojans meet Wednesday in college basketball action from the Galen Center. We will look at this from a betting perspective and determine the best bets for this game. Here’s a UTSA Roadrunners vs. USC Trojans prediction.

UTSA Roadrunners Recap

The UTSA Roadrunners come into this game looking to bounce back from an 88-64 loss to Colorado last time out to sit at 4-6 this season. After this game, UTSA will head home for a game against Seattle.

Roadrunners Lose Three In A Row

Jamir Simpson leads the Roadrunners in scoring with 18.9 PPG with 5.3 RPG as the lone double-digit scorer for UTSA so far this season. Austin Nunez has 7.7 PPG with a team-high 2.5 APG to lead the Roadrunners in assists while Macaleab Rich has 7.3 PPG with 2.6 RPG. Kaidon Rayfield has 7.7 PPG with a team-high 6.8 RPG to lead UTSA in rebounding while Dorian Hayes has 8.3 PPG up to this point in the year. As a team, UTSA is averaging 71.7 PPG on 39.7% shooting from the field, 29.6% from behind the arc and 61.9% from the foul line so far this season.

USC Trojans Recap

The USC Trojans will be out to add on to their 68-61 win over Washington State last time out to sit at 10-1 this season. After this game, USC will head on the road for a game against Michigan.

Trojans Win Back-To-Back Games

Chad Baker-Mazara has 21.6 PPG with 5.5 RPG and 2.9 APG while Rodney Rice has 20.3 PPG with 3.3 RPG and 6 APG so far this season. Ezra Ausar has 16.8 PPG with 5.6 RPG and Jacob Cofie has 10.2 PPG with 7.1 RPG to lead USC in rebounding and to round out the group of double-digit scorers for USC up to this point in the year. As a team, USC is averaging 87.5 PPG on 48.2% shooting from the field, 37.3% from three and 73.9% from the foul line this season.

UTSA Roadrunners vs. USC Trojans Prediction

I’m on USC here. It’s a big number to be giving up here with the Trojans, but UTSA has been getting smacked around in a lot of these step up spots as of late and I just think that this is a bad matchup for the Roadrunners. USC has a bunch of different scorers that can do damage and I think that they whoop up on UTSA here. Give me USC.

Chris Ruffolo's Pick: USC -23.5

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