LSU's Mike Nwoko (1) is introduced before the start of the DePaul game at Raider Arena in Niceville, Fla., Nov. 29, 2025. The Tigers won the Emerald Coast Classic championship 96-63. (Tyler Orsburn/News Herald)
Tyler Orsburn/News Herald / USA TODAY NETWORK via Imagn Images

Southern Miss vs LSU Prediction 12/29/2025 Today’s College Basketball Picks

Pick details

MATCHUP Southern Mississippi Golden Eagles LSU Tigers
Team Records 7-6 11-1
Spread +18.5 -102 -18.5 -118
Moneyline +1500 -3600
Total Over 158.5 (-105) Under 158.5 (-115)
Where Pete Maravich Assembly Center, Baton Rouge, LA
When Monday, December 29, 2025
Time 08:00 PM EST
TV SECN+

In this article we will formulate a Southern Miss vs LSU prediction for this College Basketball game on Monday, December 29th at the Pete Maravich Assembly Center in Baton Rouge, Louisiana. Let’s take a look at the prediction for this College Basketball matchup.

Southern Miss Golden Eagles Betting Preview

The Southern Miss Golden Eagles are 7-6 this season after they lost to Arkansas State by a score of 93-86 in their last game. Southern Miss trailed 39-32 at halftime, but they did score 54 points in the second half in the loss. The Golden Eagles shot 48% from the field, 44% on three pointers, and 93% on free throws in the game. Tylik Weeks led Southern Miss with 25 points and five rebounds, while Brewer Carruth added 16 points and six rebounds in the loss. 

Prior to that game, Southern Miss defeated Louisiana by a score of 62-54, but lost to Ole Miss by a score of 71-67 before that. The Golden Eagles have scored 76.5 points per game with 37.6 rebounds and 12.6 assists per game, while they have allowed 72.5 points against per game this season. Tylik Weeks is averaging 17.8 points and 6.2 rebounds per game, while Isaac Taveras is averaging 15.8 points and 6.7 rebounds per game for the Golden Eagles. Southern Miss is shooting 46.4% from the field, 72.5% on free throws, and 31.2% on three pointers this season. 

LSU Tigers Betting Preview

The LSU Tigers are 11-1 this year after they defeated Prairie View A&M by a score of 104-90 in their last game. LSU trailed 56-51 at halftime, but they scored 53 points in the second half to avoid the terrible loss. The Tigers shot 47% from the field, 35% on three pointers, and 88% on free throws in the game. Marquel Sutton led LSU with 21 points and 13 rebounds, while Dedan Thomas Jr added 21 points and seven assists in the win. 

Prior to that game, LSU defeated SELA by a score of 78-65 and SMU by a score of 89-77. The Tigers have scored 88.9 points per game with 39.8 rebounds and 15.7 assists per game, while they have allowed 71.8 points against per game this season. Dedan Thomas Jr is averaging 15.7 points and 6.7 assists per game, while Mike Nwoko is averaging 15.6 points and 5.5 rebounds per game for the Tigers. LSU is shooting 51.4% from the field, 78.4% on free throws, and 33.6% on three pointers this year. 

Why the LSU Tigers will win

  • LSU has won each of its last 16 games against non-Conference opponents at Pete Maravich Assembly Center.
  • Southern Miss has lost eight of its last nine night games against the Southeastern Conference.
  • Southern Miss has lost the first half in each of its last four games against the Southeastern Conference.

Why the Southern Miss Golden Eagles will win

  • Southern Miss has won each of its last five night games against non-AP-ranked opponents.

Total Points Facts

  • Each of LSU’s last five home games against the Sun Belt Conference have produced a total of 155 or fewer points.
  • Twelve of Southern Miss’ last 14 games against the Southeastern Conference Conference have produced a total of 154 or fewer points.

Southern Miss vs LSU Prediction 

LSU comes into this contest with an 11-1 record to start the season, but they are not ranked (as of Sunday night) and they have struggled to get by two lesser teams in their last two games. The Tigers are shooting 51% from the field and they have scored 78 points or more in four of their last five. Southern Miss has alternated wins and losses over their last five games and they are shooting 46% from the field. The Golden Eagles are 1-4 on the road this year, but they have lost by 19 points just once on the season. Take Southern Miss and the points here.

David Racey's Pick: Southern Miss +18.5

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