SMU vs Louisville Prediction 3/11/2026 Today's College Basketball Picks

MATCHUP	SMU Mustangs	Louisville Cardinals
Team Records	20-12	22-9
Where	Madison Square Garden, New York, NY
When	Wednesday, March 11, 2026
Time	02:30 PM EDT
TV	ESPN

In this article we will formulate a SMU vs Louisville prediction for this College Basketball game on Wednesday, March 11th at the Spectrum Center in Charlotte, North Carolina. Let’s take a look at the prediction for this College Basketball matchup.

SMU Mustangs Betting Preview

The SMU Mustangs are 20-12 (8-10) this season after they defeated Syracuse by a score of 86-69 in their last game. SMU led 39-38 at halftime and they scored 47 points in the second half for the easy win. The Mustangs shot 47% from the field, 33% on three pointers, and 88% on free throws in the game. Boopie Miller led SMU with 25 points and seven rebounds, while Jaron Pierre Jr added 21 points and five rebounds in the win.

Prior to that game, SMU lost to Florida State by a score of 91-78 and Miami by a score of 77-69. The Mustangs have scored 85.0 points per game with 37.6 rebounds and 17.1 assists per game, while they have allowed 78.4 points against per game this season. Boopie Miller is averaging 19.4 points and 6.6 assists per game, while Jaron Pierre Jr is averaging 17.5 points and 5.0 rebounds per game for the Mustangs. SMU is shooting 49.3% from the field, 74.2% on free throws, and 37.8% on three pointers this season.

Louisville Cardinals Betting Preview

The Louisville Cardinals are 22-9 (11-7) this year after they defeated Miami by a score of 92-89 in their last game. Louisville led 46-37 at halftime, but they were outscored 52-46 in the second half in the win. The Cardinals shot 60% from the field, 50% on three pointers, and 67% on free throws in the game. Ryan Conwell led Louisville with 24 points and two assists, while J’Vonne Hadley added 16 points and two rebounds in the win.

Prior to that game, Louisville defeated Syracuse by a score of 77-62, but did lose to Clemson by a score of 80-75 before that. The Cardinals have scored 85.9 points per game with 38.7 rebounds and 17.4 assists per game, while they have allowed 72.5 points against per game this season. Ryan Conwell is averaging 18.7 points and 4.7 rebounds per game, while Mikel Brown Jr. (OUT) is averaging 18.2 points and 4.7 assists per game for the Cardinals. Louisville is shooting 47.2% from the field, 77.1% on free throws, and 36.3% on three pointers this season.

Why the Louisville Cardinals will win

SMU has lost eight of its last nine day games against AP-ranked opponents.
Louisville has won 29 of its last 33 games against non-AP-ranked opponents.
SMU has lost the first half in 17 of its last 21 games against AP-ranked opponents.

Why the SMU Mustangs will win

SMU has won four of its last five games against the Atlantic Coast Conference at neutral venues.
Louisville has lost each of its last three Conference Tournament day games.
Louisville has lost the first half in three of its last four games as an AP-ranked team.

Total Points Facts

Thirty-six of Louisville’s last 37 Wednesday games against Conference opponents have produced a total of 162 or fewer points.
Each of SMU’s last six Wednesday games against Conference opponents have produced a total of 158 or fewer points.

Matchup/League Facts

Louisville ranks 16th among Division 1 teams for point differential per game this season (+13.4).
Louisville ranks 17th among Division 1 teams for points per game this season (85.9).
SMU ranks 10th among Division 1 teams for field goals made per game this season (30.9).
SMU ranks 20th among Division 1 teams for points per game this season (85.0).