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Pittsburgh vs Louisville Prediction 3/1/25 College Basketball Picks

Pick details

Louisville (22-6) vs Pittsburgh (16-12)

March 1, 2025 at 06:00 PM EST

The Line: Betting Odds: Louisville -10.5 — Over/Under: 150.5

(Get latest betting odds)

The Pitt Panthers are visiting the Louisville Cardinals on Saturday, Match 1st at the KFC Yum! Center. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Pitt Panthers vs Louisville Cardinals Prediction. We will examine:

The Louisville Cardinals recent form and player performance

The Pitt Panthers recent form and player performance

Recent betting trends and streaks involving Louisville Cardinals

Recent betting trends and streaks involving Pitt Panthers

Recent betting trends in games played between Pitt Panthersand Louisville Cardinals

A summary that ties it all together and produces a favorable betting outcome for Pitt Panthers vs Louisville Cardinals game

Louisville Cardinals Preview

The Louisville Cardinals have a 22-6 record this season and are sitting on the second place of the ACC. Louisville is coming off a 71-66 win in Virginia Tech. The Cardinals are 16-12 against the spread, and 10-18 in over/under, while having a 11-3 home record. 

Offensively, Louisville is averaging 79.5 points per game, which ranks 51st in the nation. Defensively, they are allowing 69.3 points per game (96th). The Cardinals shoot with 45.2% from the field (156th), and with 32.7% from beyond the arc (259th). The Cardinals shoot with 74.7% from the free throw line (88th), and are grabbing 37.5 rebounds per game (72nd).

Chucky Hepburn leads Louisville in scoring this season, with an average of 15.6 points, 3.3 rebounds and a team-high 6 assists, while Terrence Edwards adds 14.8 points and 3.9 rebounds per game.

Pitt Panthers Preview

The Pitt Panthers have a 16-12 record this season and are sitting on the 9th place of the ACC. Pitt is coming off a 67-73 loss in Georgia Tech. The Panthers are 12-15 against the spread, and 15-11-2 in over/under, while having a 3-7 road record. 

Offensively, Pitt is averaging 76.8 points per game, which ranks 103rd in the nation. Defensively, they allow 71.3 points per game (164th). The Panthers shoot with 45.6% from the field (132nd), and with 35.3% from beyond the arc (108th). The Panthers shoot with 78.4% from the free-throw line, which is the 16th-best in the nation, and are grabbing 33.3 rebounds per game (295th).

Jaland Lowe leads Pitt in scoring with an average of 16.7 points, 4 rebounds and a team-high 5.3 assists, while Ishmael Leggett adds 16.5 points and 5.8 rebounds per game.

Why the Louisville Cardinals will win

  • Louisville has won each of its last 11 home games against non-AP-ranked opponents.
  • Pittsburgh has lost each of its last four road games.
  • Louisville has won the first half in each of its last 18 games against the Atlantic Coast Conference.

Why the Pittsburgh Panthers will win

  • Pittsburgh has won each of its last eight Saturday night games.
  • Pittsburgh has won the first half in five of its last six games against Louisville.

Total Points Facts

  • Each of Pittsburgh’s last 10 games against Conference opponents have produced a total of 150 or fewer points.
  • Each of the last seven night games between Pittsburgh and Louisville have produced a total of 148 or fewer points.

Matchup/League Facts

  • Louisville ranks 9th among Division 1 teams for three-point field goal attempts per game this season (29.8).
  • Louisville ranks 28th among Division 1 teams for opponent free throw attempts per game this season (15.4).
  • Pittsburgh ranks 15th among Division 1 teams for free throw percentage this season (78.4%).
  • Pittsburgh ranks 20th among Division 1 teams for opponent steals per game this season (5.3).

Pitt Panthers vs Louisville Cardinals Prediction

Pitt is 5-1 in their last 6 meetings against Louisville, and are 6-1 against the spread in their last 7 meetings. Over is 3-1 in their last 4 meetings, and in their previous meeting earlier this season, Louisville won 82-78 on the road, covering the spread, as the game went over the point total.

In this Pitt Panthers vs Louisville Cardinals Prediction, Louisville is coming as -10.5 home favorites. Louisville is rightfully favored, as they have a better record this season, and have been terrific at home, while Pitt is struggling on the road. Louisville is playing good basketball lately, as they are 9-1 in their last 10 games, while Pitt is struggling, as they are 2-6 in their last 8 games and 0-4-1 against the spread in their last 5. Louisville has already won Pitt this season on the road, and given their recent form, I expect them to do so again today. Take the Louisville Cardinals and lay the points at home.

Nikos Lagouretos's Pick: Louisville Cardinals -10.5

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