Notre Dame vs Pittsburgh Prediction 2/21/2026 Today’s College Basketball Picks

In this article, we will formulate a Notre Dame vs Pittsburgh Prediction for this college basketball game on Saturday, February 21st. Let’s take a look at the prediction for this college basketball matchup.

Pittsburgh Panthers Preview

The Pittsburgh Panthers have a 9-17 overall record and a 2-11 record in the ACC. They are coming off a 79-65 road loss against North Carolina and their previous three games were a 70-54 home loss against Duke, an 86-67 home loss against SMU and a 67-47 road loss against Virginia.

Offensively, Pittsburgh averages 69.9 points per game, while allowing 71.8 points per game defensively. The Panthers shoot with 43% from the field and grab 34.7 rebounds per game, while dishing out 13.2 assists per game. They average 3.2 blocks per game and 6.5 steals per game defensively.

Cameron Corhen leads Pittsburgh in scoring, with an average of 12.4 points per game, while shooting with 52.5% from the field and 62.8% from the free throw line, adding a team-high 7.2 rebounds. Damarco Minor leads the team in assists with 3.4 per game.

Notre Dame Fighting Irish Preview

The Notre Dame Fighting Irish have a 12-14 overall record and a 3-10 record in the ACC. They are coming off an 89-74 home win against Georgia Tech and their previous three games were an 89-81 road loss against SMU, an 82-79 home loss against Florida State and a 76-65 road loss against Louisville.

Offensively, Notre Dame averages 74.7 points per game, while allowing 73.4 points per game defensively. The Fighting Irish shoot with 45% from the field and grab 37 rebounds per game, while dishing out 12.3 assists per game. They average 2.3 blocks per game and 4.6 steals per game defensively.

Jalen Haralson leads Notre Dame in scoring, with an average of 15.5 points per game, while shooting with 50.9% from the field and 64.1% from the free throw line, adding a team-high 2.6 assists. Carson Towt is the team’s leading rebounder with 9.3 per game.

Notre Dame Fighting Irish @ Pittsburgh Panthers Betting Trends: February 21, 2026

Why the Pittsburgh Panthers will win

• Notre Dame has lost each of its last nine Saturday day road games against Conference opponents.
• The home team has won four of Notre Dame’s last five games.
• Notre Dame has lost the first half in each of its last five road games.

Why the Notre Dame Fighting Irish will win

• Pittsburgh has lost each of its last eight day games against Conference opponents.
• Notre Dame has won seven of its last eight games against Pittsburgh.
• Pittsburgh has lost the first half in each of its last nine games.

Notre Dame vs Pittsburgh Prediction

In this Notre Dame vs Pittsburgh Prediction, Pittsburgh is coming as -2.5 home favorites. Notre Dame has been the better team this season and have also been better against the spread, but have been struggling mightily lately, with a 2-8 record in their last 10 games. Pitt has also been in terrible form, with a 1-8 record in its last 9 games and 2-7 against the spread, so I see no value on either side. Both teams are 14-6 to the over in their last 20 games combined and the over is 5-1 in their last 6 meetings, so I expect another high-scoring affair. Take the over 138.5 points.

Nikos Lagouretos's Pick: Over 138.5