Nov 5, 2026; Durham, North Carolina, USA;  Duke Blue Devils guard John Blackwell (13) lays the ball up over Coastal Carolina Chanticleers guard Jaylen Cross (9) during the second half at Cameron Indoor Stadium.  Mandatory Credit: Rob Kinnan-Imagn Images
IMAGN IMAGES via Reuters Connect

Michigan State vs Duke Prediction 11/10/2026 Today’s College Basketball Picks

Pick details

Michigan State vs Duke Odds and Matchup Info
MATCHUP Michigan State Spartans Duke Blue Devils
Team Records 2-0 2-0
Spread +6.5 -110 -6.5 -110
Moneyline +230 -285
Total Over 147.5 (-115) Under 147.5 (-105)
Where United Center, Chicago, IL
When Tuesday, November 10, 2026
Time 07:00 PM EST
TV ESPN

Duke vs Michigan State Prediction

In this Duke vs Michigan State Prediction, Duke is coming as -6.5 road favorites. Both teams have been undefeated this season, having won both of their games played and Michigan State has also been perfect against the spread. Both teams have been excellent in the offensive end, averaging 192 points per game combined and they also play very good defense, allowing just 111 points per game combined. Duke has been dominating its recent meetings against Michigan State, as they are 8-2 in their last 10 meetings and 7-3 against the spread and currently rank 2nd in the entire country in the Oct 19th AP Poll. The line is not too big so I will lay the -6.5 with Duke on the road in this one.

Michigan State Spartans Preview

The Michigan State Spartans have a 2-0 overall record and a 2-0 home record and a 0-0 neutral record. They are coming off a 91-61 home win against Toledo and will face Northern Iowa and Tennessee next.

Offensively, they are averaging 93.5 points per game (ranking 49th in the nation), while allowing 60 points per game defensively (ranking 58th in the nation) and have a 128.3 offensive rating (ranking 44th) and a 82.3 defensive rating (ranking 57th). The Spartans are shooting 54.6% from the field (ranking 18th) and 40.4% from beyond the arc (ranking 51st), while allowing their opponents to shoot with 34.5% from the field (ranking 50th) and 26.2% from the 3-point range (ranking 78th). They are shooting with a 59.4% from the free-throw line (ranking 327th). They are grabbing 49 rebounds per game (ranking 22nd) and allow 27 rebounds per game off their opponents (20th), while averaging 22 assists per game (ranking 25th) and allowing their opponents to dish 12 assists per game (137th). They average 5.5 blocks per game (ranking 51st) and 9 steals per game (ranking 111st), while committing 13 turnovers per game (ranking 194th) and forcing their opponents into 14 turnovers per game (ranking 153rd).

Jeremy Fears Jr. leads Michigan State in scoring, averaging 12.5 ppg on 53.3% shooting from the field, also adding a team-high 10 assists per game. Jordan Scott follows with 11.5 ppg on 45.5% shooting from the field. Coen Carr follows with 11 ppg on 50% shooting from the field. Anton Bonke leads the team in rebounds with 10 per game.

Duke Blue Devils Preview

The Duke Blue Devils have a 2-0 overall record and a 2-0 home record and a 0-0 neutral record. They are coming off a 113-52 home win against Coastal Carolina and will face Southern Illinois–Edwardsville and Illinois next.

Offensively, they are averaging 98.5 points per game (ranking 30th in the nation), while allowing 51 points per game defensively (ranking 15th in the nation) and have a 131.3 offensive rating (ranking 35th) and a 68.0 defensive rating (ranking 8th). The Blue Devils are shooting 55.4% from the field (ranking 17th) and 34.1% from beyond the arc (ranking 161st), while allowing their opponents to shoot with 32.2% from the field (ranking 32nd) and 23.1% from the 3-point range (ranking 41st). They are shooting with a 71.6% from the free-throw line (ranking 137th). They are grabbing 45 rebounds per game (ranking 60th) and allow 27.5 rebounds per game off their opponents (32nd), while averaging 20 assists per game (ranking 48th) and allowing their opponents to dish 10.5 assists per game (86th). They average 7.5 blocks per game (ranking 10th) and 14 steals per game (ranking 11th), while committing 14 turnovers per game (ranking 237th) and forcing their opponents into 20.5 turnovers per game (ranking 21st).

Patrick Ngongba II leads Duke in scoring, averaging 19 ppg on 68.4% shooting from the field, also adding a team-high 8 rebounds per game. Dame Sarr follows with 14 ppg on 100% shooting from the field. Joaquim Boumtje Boumtje follows with 12 ppg on 46.2% shooting from the field. Cayden Boozer leads the team in assists with 7.5 per game.

Michigan State Spartans @ Duke Blue Devils Betting Trends: November 10, 2026

 

2026-27 college basketball handicapper records, ranked by profit (bet to win $100).
CapperWonLostWin %Profit (to win $100)
Brad Francis12285.71%+954
Rodd Zawacky11473.33%+827
Jay Yang11378.57%+770
Jeremy Conn16866.67%+715
Shane Mickle201458.82%+469

See the full rankings: Best College Basketball Handicappers

Why the Duke Blue Devils will win

  • Duke has won each of its last 11 November games as a top-15 AP-ranked team.
  • Michigan State has lost eight of its last nine games against Top 5 AP-ranked opponents at a neutral venue.
  • Michigan State has lost the first half in each of its last six night games against Top 5 AP-ranked opponents.

Why the Michigan State Spartans will win

  • Michigan State has won each of its last nine November night games as an AP-ranked team.
  • Duke has lost four of its last five night games against teams with an AP Ranking of 5.
  • Duke has lost the first half in each of its last four night games against teams with an AP Ranking of 5.

Total Points Facts

  • Seven of Duke’s last eight games against Top 5 AP-ranked opponents at a neutral venue have produced a total of 147 or fewer points.
  • Five of Michigan State’s last six games at United Center have produced a total of 147 or fewer points.

Matchup/League Facts

  • Duke ranks 3rd among Division 1 teams for defensive rating this season (68.4).
  • Duke ranks 6th among Division 1 teams for net rating this season (+63.7).
  • Michigan State ranks T17th among Division 1 teams for opponent rebounds per game this season (27.0).
  • Michigan State ranks 18th among Division 1 teams for field goal percentage this season (54.6%).

Nick Lagouretos's Pick: Duke -6.5

2026-27 NBA handicapper records, ranked by profit ($100 base bet).
CapperWonLostWin %Profit (per $100 bet)
Jay Briggs321864.00%+1280
John Ryan12380.00%+880
Jay Yang292059.18%+647
Sean Murphy201360.61%+553
Stephen Nover9375.00%+544
VIP Sports Syndicate12763.16%+422
Nick Lagouretos20100.00%+200
Damian Sosh131056.52%+194
Shane Mickle312753.45%+172

See the full Best NBA Handicappers rankings

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