Indiana Hoosiers guard Lamar Wilkerson (3) shoots the ball over Louisville Cardinals guard Ryan Conwell (3) during a game Saturday, Dec. 6, 2025, at Gainbridge Fieldhouse in Indianapolis. Louisville defeated Indiana 87-78.
Christine Tannous/IndyStar / USA TODAY NETWORK via Imagn Images

Memphis vs Louisville Prediction 12/13/2025 Today’s College Basketball Picks

Pick details

MATCHUP Memphis Tigers Louisville Cardinals
Team Records 4-4 8-1
Spread +15.5 -108 -15.5 -112
Moneyline +1000 -1800
Total Over 160.5 (-108) Under 160.5 (-112)
Where KFC Yum! Center, Louisville, KY
When Saturday, December 13, 2025
Time 03:30 PM EST
TV ESPN

The Memphis Tigers and Louisville Cardinals meet Saturday in the college basketball action at the KFC Yum! Center. Here’s a Memphis vs Louisville Prediction. This article will include a Memphis vs Louisville Pick.

Memphis Tigers Betting Preview


The Memphis Tigers beat Baylor and New Orleans, and they play Louisville next. Memphis has won its last 3 games.

The Memphis Tigers are averaging 76 points on 43.2 percent shooting and allowing 74.3 points on 41.3 percent shooting. Dug McDaniel is averaging 13.9 points and 3.1 rebounds, while Zach Davis is averaging 9.1 points and 5.3 rebounds. Sincere Parker is dishing 1.4 assists and Julius Thedford is grabbing 5.1 rebounds. The Memphis Tigers are shooting 32.4 percent from beyond the arc and 70.2 percent from the free throw line. The Memphis Tigers are allowing 31.8 percent shooting from deep and are grabbing 32.6 rebounds per game.

Louisville Cardinals Betting Preview


The Louisville Cardinals lost to Arkansas, beat Indiana, and they play Tennessee next. Louisville has won 8 of its last 9 games.

The Louisville Cardinals are averaging 105.6 points on 47.2 percent shooting and allowing 76.1 points on 37.4 percent shooting. Ryan Conwell is averaging 19.7 points and 4.8 rebounds, while Mikel Brown Jr. is averaging 16.7 points and 3.2 rebounds. Isaac McKneely is the third double-digit scorer and Sananda Fru is grabbing 6.2 rebounds. The Louisville Cardinals are shooting 36 percent from beyond the arc and 77.1 percent from the free throw line. The Louisville Cardinals are allowing 29.7 percent shooting from deep and are grabbing 46.6 rebounds per game.

Why the Louisville Cardinals will win

  • Louisville has won each of its last 17 games at KFC Yum! Center.

Why the Memphis Tigers will win

  • Memphis has won six of its last seven day games against AP-ranked opponents.

Total Points Facts

  • Eleven of Memphis’ last 12 games against non-Conference opponents have produced a total of 160 or fewer points.
  • Eighteen of Louisville’s last 21 day games against non-Conference opponents at KFC Yum! Center have produced a total of 156 or fewer points.

Matchup/League Facts

  • Louisville ranks 6th among Division 1 teams for point differential per game this season (+26.2).
  • Louisville ranks 6th among Division 1 teams for net rating this season (+35.9).

Memphis vs Louisville Prediction


Louisville has a couple of nice wins over Kentucky and Indiana, and being at home doesn’t hurt either. However, this line is nuts. Memphis doesn’t have a sexy SU record, but it hung around with Purdue and just upset Baylor. Memphis has athletes to give good teams fits, and it’s defending at a decent level. Memphis is also coming off its best week of the season. Memphis is a team that’s starting to find its stride and has a chance to make a seal statement here. Not sure the Tigers have the scoring to pull off the upset, but this should still be a competitive game. I’ll gladly grab the free buckets.

Randy Chambers's Pick: Memphis +15.5

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