Louisville vs Duke Prediction 1/26/2026 Today’s College Basketball Picks

In this article, we will formulate a Louisville vs Duke Prediction for this College Basketball game on Monday, January 26th. Let’s take a look at the prediction for this College Basketball matchup.

Duke Blue Devils Preview

The Duke Blue Devils have an 18-1 overall record this season and a 7-0 conference record. They are coming off a 90-69 home win against Wake Forest and their previous three games were an 80-50 away win against Stanford, a 71-56 away win against California, and an 82-75 home win against SMU.

Offensively, Duke averages 85.5 points per game, while allowing 65.1 points per game defensively. The Blue Devils shoot with 49.8% from the field and grab 40.2 rebounds per game, while dishing out 17.5 assists per game. They average 4.1 blocks per game and 8.5 steals per game defensively.

Cameron Boozer leads Duke in scoring, with an average of 23.7 points per game, while shooting with 58.4% from the field and 76.4% from the free throw line, and is also the team’s leading rebounder with 9.9 per game, adding a team-high 4.1 assists.

Louisville Cardinals Preview

The Louisville Cardinals have a 14-5 overall record this season and a 4-3 conference record. They are coming off an 85-71 home win against Virginia Tech and their previous three games were a 100-59 away win against Pittsburgh, a 79-70 home win against Virginia and a 75-62 home win against Boston College.

Offensively, Louisville averages 87.8 points per game, while allowing 69.6 points per game defensively. The Cardinals shoot with 47% from the field and grab 41.4 rebounds per game, while dishing out 17.8 assists per game. They average 3.3 blocks per game and 7.3 steals per game defensively.

Ryan Conwell leads Louisville in scoring, with an average of 19.5 points per game, while shooting with 40.2% from the field and 82.6% from the free throw line. Sandana Fru is the team’s leading rebounder with 7.1 per game.

Louisville Cardinals @ Duke Blue Devils Betting Trends: January 26, 2026

Why the Duke Blue Devils will win

• Duke has won each of its last 26 games at Cameron Indoor Stadium.
• Louisville has lost 16 of its last 18 night games against AP-ranked opponents.
• Duke has won the first half in each of its last 11 games as a top-5 AP-ranked team at Cameron Indoor Stadium.

Why the Louisville Cardinals will win

• Louisville has won 15 of its last 18 night games against Conference opponents.
• Duke has lost three of its last four games as a top-5 AP-ranked team against an AP-ranked team at Cameron Indoor Stadium.
• Louisville has won the first half in 17 of its last 19 night games against Conference opponents.

Total Points Facts

• Each of the last 13 games between Louisville and Duke have produced a total of 157 or fewer points.
• Thirty-three of Louisville’s last 38 games against Top 10 AP-ranked opponents have produced a total of 157 or fewer points.

Louisville vs Duke Prediction

In this Louisville vs Duke Prediction, Duke is coming as -6.5 home favorites. Duke has been almost perfect this season with just one defeat in 19 games played and is 4-1 against the spread in its last 5 games. On the flip side, Louisville is just 3-3 in its last 6 games and 1-5 against the spread and are going up against a top-45 defense in Duke, so I don’t expect them to have much success on the road. Take Duke and lay the points at home.

Nikos Lagouretos's Pick: Duke -6.5