IUPUI vs Grand Canyon Prediction 12/22/2025 Today’s College Basketball Picks

The IU Indy Jaguars and the Grand Canyon Lopes meet Monday in college basketball action from the Global Credit Union Arena. We will look at this from a betting perspective and determine the best bets for this game. Here’s an IU Indy Jaguars vs. Grand Canyon Lopes prediction.

IU Indy Jaguars Recap

The IU Indy Jaguars come into this game looking to add on to their 126-73 win over subdivision Miami-Middletown to sit at 4-9 this season. After this game, IU Indy will head on the road for a game against Cleveland State.

Jaguars Snap Three-Game Skid

Kyler D’Augustino leads the Jaguars in scoring with 16.2 PPG along with 3 RPG and 3.2 APG while Matt Compas has 12.5 PPG and Maguire Mitchell has 10.6 PPG to cap off the trio of double-digit scorers for IU Indy so far this season. Kameron Tinsley has 9.7 PPG with 2.7 RPG while Micah Davis has 8.5 PPG with 2.3 RPG and 3.1 APG. Jaxon Edwards has 8.1 PPG with 4.1 RPG and 2 APG while Finley Woodward has 8.1 PPG with team-highs of 5.5 RPG and 5.2 APG to lead the Jaguars in rebounding and assists up to this point in the year. As a team, IU Indy is averaging 87 PPG on 44.8% shooting from the field, 31.8% from three and 70.2% from the foul line this season.

Grand Canyon Lopes Recap

The Grand Canyon Lopes come into this game looking to add on to their 82-70 win over Wyoming last time out to sit at 7-4 this season. After this game, Grand Canyon will take on Colorado State at home.

Lopes Win Back-To-Back Games

Jaden Henley leads the Lopes in scoring with 16.7 PPG along with 4.5 RPG and 2.2 APG while Makaih Williams has 11.5 PPG with 2 RPG and 2.3 APG and Nana Owusu-Anane has 10 PPG with team-highs of 9.3 RPG and 2.5 APG to lead the Lopes in rebounding and assists and to cap off the trio of double-digit scorers for Grand Canyon so far this season. Caleb Shaw has 9.8 PPG with 3.8 RPG as well this season. As a team, Grand Canyon is averaging 75.5 PPG on 44.3% shooting from the field, 29.7% from three and 75.6% from the foul line this season.

IU Indy Jaguars @ Grand Canyon Antelopes Betting Trends: December 22, 2025

Why the Grand Canyon Antelopes will win

• Grand Canyon has won each of its last 12 games at Global Credit Union Arena at GCU when playing with a rest disadvantage.
• IU Indy has lost each of its last 14 Monday night games against non-Conference opponents.
• Grand Canyon has won the first half in 10 of its last 11 games against non-Conference opponents at Global Credit Union Arena at GCU.

Matchup/League Facts

• Grand Canyon ranks 24th among Division 1 teams for opponent rebounds per game this season (30.4).
• Grand Canyon ranks 46th among Division 1 teams for rebound percentage this season (55.3%).
• IU Indy ranks 1st among Division 1 teams for field goal attempts per game this season (73.7).
• IU Indy ranks 1st among Division 1 teams for pace this season (81.1).

IU Indy Jaguars vs. Grand Canyon Lopes Prediction

I’m on Grand Canyon here. IU Indy has been so poor defensively this season that while their offense is capable of keeping this team in games, it’s truly hard to trust them to do anything. Grand Canyon has been really solid at home over the years and have been good up to this point and I think the Lopes steamroll IU Indy in this one. Give me Grand Canyon.

Chris Ruffolo's Pick: Grand Canyon -25.5