Iowa State vs Creighton Prediction 11/25/2025 Today’s College Basketball Picks

In this article we will formulate an Iowa State vs Creighton prediction for this College Basketball game on Tuesday, November 25th at Michelob ULTRA Arena in Las Vegas, Nevada. Let’s take a look at the prediction for this College Basketball matchup.

Iowa State Cyclones Betting Preview

The Iowa State Cyclones are 5-0 this season after they defeated St. John’s by a score of 83-82 in their last game. Iowa State trailed 45-43 at halftime and added 40 points in the second half to escape with the one-point win. The Cyclones shot 44% from the field, 41% on three pointers, and 80% on free throws in the game. Milan Momcilovic led Iowa State with 23 points and three rebounds, while Joshua Jefferson added 17 points and eight rebounds in the win. 

Prior to that game, Iowa State defeated Stonehill by a score of 96-57 and Mississippi State by a score of 96-80. The Cyclones have scored 95.5 points per game with 37.5 rebounds and 18.5 assists per game, while they have allowed 62.3 points against per game this season. Tamin Lipsey (questionable) is averaging 19.0 points and 5.3 assists per game, while Joshua Jefferson is averaging 18.8 points and 7.8 rebounds per game for the Cyclones. Iowa State is shooting 54.2% from the field, 66.7% on free throws, and 35.6% on three pointers this season. 

Creighton Bluejays Betting Preview

The Creighton Bluejays are 3-2 this year after they lost to Baylor by a score of 81-74 in their last game. Creighton trailed 44-36 at halftime, but did win the second half by a score of 38-37 in the loss. The Bluejays shot 47% from the field, 38% on three pointers, and 90% on free throws in the game. Hudson Greer led Creighton with 16 points and three rebounds, while Josh Dix added 15 points and six assists in the loss. 

Prior to that game, Creighton defeated North Dakota by a score of 75-60 and UMES by a score of 84-45. The Bluejays have scored 78.5 points per game with 42.5 rebounds and 16.8 assists per game, while they have allowed 67.8 points against per game this season. Blake Harper is averaging 13.0 points and 7.5 rebounds per game, while Josh Dix is averaging 11.0 points and 2.5 rebounds per game for the Bluejays. Creighton is shooting 45.1% from the field, 67.9% on free throws, and 27% on three pointers this year. 

Why the Creighton Bluejays will win

• Creighton has won three of its last four games against the Big 12 Conference.

Why the Iowa State Cyclones will win

• Iowa State has won each of its last six day games against non-Conference opponents.
• Creighton has lost four of its last five games against AP-ranked opponents at a neutral venue.

Total Points Facts

• Each of Iowa State’s last four games have produced a total of 153+ points.
• Five of Creighton’s last six games at a neutral venue have produced a total of 152+ points.

Iowa State vs Creighton Prediction 

Iowa State comes into this contest with a 5-0 record on the season and they just beat St. John’s on Monday, but they may be without their leading scorer here. The Cyclones are shooting 54% from the field and they have scored 83+ in five straight games. Creighton has an ugly loss to Gonzaga earlier this month and a seven point loss to Baylor yesterday, and they are shooting 45% from the field. The Bluejays are not as good as they were last season, but I think they can hang around if Lipsey is out for Iowa State. Take Creighton and the points here.

David Racey's Pick: Creighton +9.5