Duke vs Notre Dame Prediction 2/24/2026 Today’s College Basketball Picks

The Duke Blue Devils and the Notre Dame Fighting Irish meet Tuesday in college basketball action from Purcell Pavilion. Here’s a Duke vs Notre Dame prediction. We will look at this from a betting perspective and determine the best Duke vs Notre Dame pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.

Duke Blue Devils Betting Preview

The Blue Devils managed to win 11 straight games out of the gate to start the season. After a loss to Texas Tech came more victories over Georgia Tech, Florida State, Louisville, SMU, Cal, Stanford, Wake Forest, Louisville, Virginia Tech and Boston College, then a loss to UNC. The next three were wins over Pitt, Clemson and Syracuse, giving the Blue Devils a 24-2 run through 26 games.

On Saturday versus Michigan the Blue Devils were hanging on to a 35-33 advantage by the second half. Duke hit a 33-30 run the rest of the way and eventually powered out the victory on their home floor 68-63. Cameron Boozer led the team on his 18 points with 10 rebounds and seven assists. Isaiah Evans added 14 points with two rebounds in 24 minutes of action as well.

Notre Dame Fighting Irish Betting Preview

Over on the Notre Dame side, they were able to win 10 of their first 14 games this year, then lost to Cal, Clemson, Miami, Virginia Tech and North Carolina. After a win over Boston College game more losses to Virginia, Syracuse, Louisville, Florida State and SMU. Following a win over Georgia Tech, the Fighting Irish were left with a 12-14 run in the books after 26 outings.

Matched up against Pitt over the weekend the Irish took a 23-20 deficit into the second half. Notre Dame didn’t end up getting any closer after a 50-48 run from there and finished the game on a 73-68 defeat. Leading the team in scoring was Cole Certa with 16 points and two rebounds. Ryder Frost and Logan Imes each added 12 points while Carson Towt had 13 rebounds with seven points.

Duke Blue Devils @ Notre Dame Fighting Irish Betting Trends: February 24, 2026

Why the Notre Dame Fighting Irish will win

• The home team has won each of Notre Dame’s last three games.

Why the Duke Blue Devils will win

• Duke has won each of its last 22 games as a top-5 AP-ranked team against a non-AP-ranked team.
• Notre Dame has lost each of its last 13 games against Top 5 AP-ranked opponents.
• Notre Dame has lost the first half in each of its last 10 games against Top 10 AP-ranked opponents.

Duke vs Notre Dame Prediction

I’ll lean toward Duke. The Blue Devils are coming off a stellar win over a great Michgian team this past weekend, thanks to 45.5 percent shooting, a 37-25 rebounding edge and a 34-24 advantage on points in the paint. The 40 percent shooting allowed on defense didn’t hurt either. Duke has won four straight games now, giving up fewer than 65 points in all four of those victories.

As for Notre Dame, they shot a tepid 40 percent from the field with 23.7 percent (9-of-38) from outside and 50 percent (7-of-14) from the line in their loss to Pitt. The Irish did pretty well on the boards and in the paint but couldn’t overcome the spotty shooting outing. Notre Dame is just 1-6 in their last seven games with 73 or more points surrendered in all of those.

Andrew Jett's Pick: Duke Blue Devils -17.5