DePaul vs Creighton Prediction 2/25/2026 Today’s College Basketball Picks

The DePaul Blue Demons and Creighton Bluejays meet Wednesday in college basketball action at the CHI Health Center Omaha. Here’s a DePaul vs. Creighton prediction. This article will include a DePaul vs. Creighton pick.

DePaul Blue Demons Betting Preview

The DePaul Blue Demons beat Seton Hall and lost to Providence, and they play Marquette next. DePaul has lost 6 of its last 9 games.

The DePaul Blue Demons are averaging 71.5 points on 44 percent shooting and allowing 69.8 points on 43.5 percent shooting. CJ Gunn is averaging 14 points and 3.7 rebounds, while Layden Blocker is averaging 11.5 points and 2.4 rebounds. NJ Benson is the third double-digit scorer, and Brandon Maclin is grabbing 4.5 rebounds. The DePaul Blue Demons are shooting 32.6 percent from beyond the arc and 69 percent from the free throw line. The DePaul Blue Demons are allowing 36.5 percent shooting from deep and are grabbing 30.4 rebounds per game.

Creighton Bluejays Betting Preview

The Creighton Bluejays lost to St. John’s and beat UConn, and they play Providence next. Creighton has lost 6 of its last 8 games.

The Creighton Bluejays are averaging 76.6 points on 45.4 percent shooting and allowing 75.5 points on 45.4 percent shooting. Josh Dix is averaging 12.1 points and 3.7 rebounds, while Austin Swartz is averaging 10.9 points and 2.6 rebounds. Jasen Green is the third double-digit scorer, and Nik Graves is grabbing 3 rebounds. The Creighton Bluejays are shooting 34.8 percent from beyond the arc and 74.9 percent from the free throw line. The Creighton Bluejays are allowing 35.3 percent shooting from deep and are grabbing 33.1 rebounds per game.

Why the Creighton Bluejays will win

• Creighton has won 23 of its last 24 games against DePaul.
• DePaul has lost 14 of its last 15 road games following a home loss.
• DePaul has lost the first half in nine of its last 10 games at CHI Health Center Omaha.

Why the DePaul Blue Demons will win

• Creighton has lost four of its last five night games.

Total Points: Facts

• Each of Creighton’s last 13 night games against conference opponents has produced a total of 143+ points.
• Four of DePaul’s last five night games against conference opponents have produced a total of 139 or fewer points.

Matchup/League Facts

• Creighton ranks 32nd among Division 1 teams for three-point field goal attempts per game this season (28.5).
• Creighton ranks 38th among Division 1 teams for three-point field goals made per game this season (9.9).

DePaul vs Creighton Prediction

DePaul has had issues winning in the Big East forever and is a team I don’t want to make a habit of backing. However, you can argue DePaul has been better this season. Heck, DePaul beat Creighton earlier this month. Creighton is talented and is usually a tough out at home, but it’s a .500 team and is 9-19 ATS on the season. Creighton isn’t a team I want to lay wagers with. This is a pass for me, but I’d want the points in my pocket if forced to pick. Creighton just hasn’t made anyone money this season; meanwhile, DePaul is 16-11 ATS.

Randy Chambers's Pick: DePaul +5.5