Clemson Tigers forward RJ Godfrey (0) drives past Cincinnati Bearcats forward Halvine Dzellat (65) Sunday, Dec. 21, 2025, during the NCAA men’s basketball game at Bon Secours Wellness Arena in Greenville, South Carolina.
Alex Martin/Greenville News / USA TODAY NETWORK via Imagn Images

Clemson vs Syracuse Prediction 12/31/2025 Today’s College Basketball Picks

Pick details

MATCHUP Clemson Tigers Syracuse Orange
Team Records 10-3 9-4
Spread -1.5 -112 +1.5 -108
Moneyline -122 +102
Total Over 142.5 (-108) Under 142.5 (-112)
Where JMA Wireless Dome, Syracuse, NY
When Wednesday, December 31, 2025
Time 02:00 PM EST
TV ESPN2

The Clemson Tigers and the Syracuse Orange meet Wednesday in college basketball action from the JMA Wireless Dome. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Clemson Tigers vs. Syracuse Orange prediction.

Clemson Tigers Recap

The Clemson Tigers come into this game looking to add on to their 68-65 win over Cincinnati last time out to sit at 10-3 this season. After this game, Clemson will head on the road for a game against Pitt.

Tigers Win 3 In A Row

RJ Godfrey leads the Tigers in scoring and rebounding with 12.1 PPG and 6.4 RPG along with 2.3 APG while Carter Welling has 10.6 PPG with 6.2 RPG this season. Jestin Porter has 10.2 PPG with 2.1 RPG to cap off the trio of double-digit scorers for Clemson so far this season. Dillon Hunter has 9.2 PPG with 3.6 RPG and 2.7 APG while Nick Davidson has 8 PPG with 4.9 RPG and Jake Wahlin has 8 PPG with 4.8 RPG as well this season. Zac Foster’s added 7.8 PPG with 2.9 RPG and 2.9 APG as well to lead the Tigers in assists so far this season. As a team, Clemson is averaging 85.1 PPG on 46.3% shooting from the field, 32.8% from three and 74.9% from the foul line this season.

Syracuse Orange Recap

The Syracuse Orange come into this game looking to add on to their 77-48 win over Stonehill last time out to sit at 9-4 this season. After this game, Syracuse will head on the road for a game against Georgia Tech.

Orange Win 3 Straight

Donnie Freeman leads the Orange in scoring with 17.5 PPG along with 5.3 RPG and 2.5 APG while Kiyan Anthony has 10.9 PPG with 2.2 RPG and William Kyle III has a team-high 8.2 RPG to lead the Orange in rebounding this season. J.J. Starling has 10.6 PPG with 3 RPG and 2.4 APG to cap off the group of double-digit scorers for Syracuse so far this season while Nate Kingz has 9.7 PPG with 4.4 RPG and Tyler Betsey has 8.3 PPG with 2.9 APG and Naithan George has 8.3 PPG with 2.9 RPG and a team-high 5 APG to lead Syracuse in assists so far this season. As a team, Syracuse is averaging 72.9 PPG on 46.3% shooting from the field, 30% from three and 58% from the foul line this season.

Clemson Tigers @ Syracuse Orange Betting Trends: December 31, 2025


Why the Syracuse Orange will win

  • Syracuse has won 10 of its last 11 home games.
  • Clemson has lost four of its last five games at JMA Wireless Dome.
  • Syracuse has won the first half in each of its last 11 home games.

Why the Clemson Tigers will win

  • Clemson has won each of its last 11 day games against Conference opponents.
  • Syracuse has lost four of its last five day games.
  • Clemson has won the first half in 10 of its last 11 day games against Conference opponents.

Total Points Facts

  • Each of Syracuse’s last six day games against Conference opponents have produced a total of 146+ points.
  • Each of Clemson’s last four games have produced a total of 133 or fewer points.

Matchup/League Facts

  • Syracuse ranks 365th among Division 1 teams for free throw percentage this season (59.0%).
  • Syracuse ranks 2nd among Division 1 teams for blocks per game this season (7.0).
  • Clemson ranks T6th among Division 1 teams for turnovers per game this season (9.2).
  • Clemson ranks 11th among Division 1 teams for opponent three-point percentage this season (27.3%).

Clemson Tigers vs. Syracuse Orange Prediction

I’m on Clemson here. I think this is going to be a low-scoring rock fight, but the thing is in this game that Syracuse is the worst free throw shooting team in the country and if this is going to be a tight game as this total kind of indicates that it will be, the Tigers’ clear edge and disparity at the free throw line is going to be a massive edge late. I’ll roll with Clemson for the road win and cover here.

Chris Ruffolo's Pick: Clemson -1.5

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