Wyoming vs Colorado Prediction 9/20/2025 Today’s College Football Picks

In this article we will formulate a Wyoming vs Colorado prediction for this College Football game on Saturday, September 20th at Folsom Field in Boulder, Colorado. Let’s take a look at the prediction for this week 4 matchup. 

Wyoming Cowboys Betting Preview

The Wyoming Cowboys are 2-1 this year after they lost to Utah by a score of 31-6 last week. Wyoming trailed just 3-0 at halftime, but they allowed 28 points in the second half in the loss. The Cowboys were out gained by a total of 541-229, went 3-12 on third downs, and lost the turnover battle by a total of 2-1 in the game. Kaden Anderson went 12-23 for 108 yards and one interception, while Samuel Harris rushed eight times for 68 yards. Chris Durr Jr caught five passes for 40 yards in the loss. The Wyoming defense recorded one sack and three tackles for loss in the game. 

Wyoming opened the 2025 season with a 10-0 win over Akron in week one and a 31-7 win over Northern Iowa in week two. The Cowboys are averaging 15.7 points per game with 186.0 passing yards and 158.7 rushing yards per game, while they are allowing 12.7 points against per game this season. Kaden Anderson has completed 58.5% of his passes for 535 yards, three touchdowns, and two interceptions, while Chris Durr Jr has caught 17 passes for 284 yards and two scores. Sam Scott is the leading rusher for Wyoming with 203 yards and one touchdown on 44 carries this year. 

Colorado Buffaloes Betting Preview

The Colorado Buffaloes are 1-2 this season after they lost to Houston by a score of 36-20 last week. Colorado trailed 10-0 after the first quarter and 16-14 at halftime, but they allowed 20 points in the second half to seal the loss. The Buffaloes were out gained by a total of 431-300, went 4-14 on third downs, and lost the turnover battle by a margin of 2-0 in the game. Ryan Staub went 19-35 for 204 yards, one touchdown, and two interceptions, while Simeon Price rushed five times for 51 yards and one touchdown. Omarion Miller caught three passes for 54 yards in the loss. The Colorado defense recorded two sacks and four tackles for loss in the defeat. 

Colorado lost to Georgia Tech in week one by a score of 27-20, but they did beat Delaware in week two by a score of 31-7. The Buffaloes are averaging 23.7 points per game with 210.3 passing yards and 124.0 rushing yards per game, while they are allowing 23.3 points against per game this season. Ryan Staub has completed 57.8% of his passes for 362 yards, three touchdowns, and two interceptions, while Sincere Brown has caught six passes for 135 yards and one score. The rushing attack is led by Simeon Price, who has ran for 135 yards and one touchdown on 19 carries this season. 

Why Colorado will beat Wyoming

The favorite has won 16 of Colorado’s last 17 games at Folsom Field.
Wyoming has lost each of its last four games against opponents from the Big 12 Conference.
The favorite has covered the spread in four of Colorado’s last five games at Folsom Field.
Wyoming has failed to cover the spread in four of its last five September games as a road underdog against non-AP-ranked teams.

Total Points Facts

Eight of Wyoming’s last nine games have gone UNDER the total points line.
Each of Colorado’s last four games against non-conference opponents have gone UNDER the total points line.

Matchup/League Facts

Colorado ranks 117th among FBS teams for yards allowed per game this season (430.0).
Colorado ranks T107th among FBS teams for 1st downs against this season (67).
Wyoming ranks T122nd among FBS teams for H1 points per game this season (6.7).
Wyoming ranks T16th among FBS teams for Q1 opponent points per game this season (1.0).

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Wyoming vs Colorado Prediction 

Colorado comes into this matchup trying to get back to .500 after last week’s loss, but they should get the win here. The Buffaloes may not be great against other power four teams, but they have way more talent than Wyoming. The Cowboys are not very good offensively and they just allowed a ton of yards to Utah last week. I expect Colorado to flex some muscle in this game, as they won’t have many chances for a blowout this season. Take Colorado to cover at home.