Western Kentucky vs LSU Prediction 11/22/2025 Today’s College Football Picks

In this article, we will formulate a Western Kentucky vs LSU Prediction for this College Football Week 13 game on Saturday, November 22nd. Let’s take a look at the prediction for this College Football matchup.

LSU Fighting Tigers Preview

LSU has a 6-4 record this season and is sitting 10th in the SEC. They are 3-7 ATS, 3-7 in Over/Under and have a 5-1 home record and a 1-3 away record. LSU is coming off a 23-22 home win against Arkansas and will face Oklahoma next.

Offensively, LSU averages 23.6 points per game, ranking 98th in the nation, while defensively, they allow 19.3 points per game, which is 20th. LSU averages 346.6 total yards per game (240.2 passing and 106.4 rushing), while allowing 329.1 total yards per game (130.9 rushing and 198.2 passing).

Garrett Nussmeier leads LSU with 1,927 passing yards with 67.4% completed passes and 12 touchdowns. Caden Durham leads the team in rushing yards with 447, while Zavion Thomas has a team-high 31 receptions for 396 receiving yards. Defensively, A.J. Haulcy has a team-high 72 total tackles (41 of them solo), while Harold Perkins leads the team in sacks, with 4, and A.J. Haulcy has a team-high 2 interceptions.

Western Kentucky Hilltoppers Preview

Western Kentucky has an 8-2 record this season and is sitting 2nd in the CUSA. They are 8-2 ATS, 5-5 in Over/Under and have a 5-1 home record and a 3-1 away record. Western Kentucky is coming off a 42-26 home win against Middle Tennessee State and will face Jacksonville State next.

Offensively, Western Kentucky averages 31.3 points per game, ranking 47th in the nation, while defensively, they allow 23.1 points per game, which is 55th. Western Kentucky averages 432.9 total yards per game (296.1 passing and 136.8 rushing), while allowing 399.0 total yards per game (175.7 rushing and 223.3 passing).

Maverick McIvor leads Western Kentucky with 1,863 passing yards with 67.1% completed passes and 12 touchdowns. George Hart III leads the team in rushing yards with 258, while Quincy Burroughs has a team-high 87 receptions for 796 receiving yards. Defensively, Jaylen Wester has a team-high 64 total tackles (28 of them solo), while Dominic Oliver leads the team in sacks, with 3.

Western Kentucky Hilltoppers @ LSU Tigers Betting Trends: Week 13

Why the LSU Tigers will win

• LSU has won each of its last 22 games against non-AP-ranked teams at Tiger Stadium.
• Western Kentucky has lost six of its last seven games against opponents from the Southeastern Conference.
• Western Kentucky has failed to cover the spread in eight of its last nine games against opponents from the Southeastern Conference.
• The favorite has covered the spread in five of LSU’s last six games.
• LSU has won the first quarter in 14 of its last 15 games against non-conference opponents at Tiger Stadium.
• LSU has won the first half in 19 of its last 20 games against non-conference opponents at Tiger Stadium.

Why the Western Kentucky Hilltoppers will win

• Western Kentucky has won each of its last three games as an underdog in Louisiana.
• LSU has lost three of its last four games.
• LSU has failed to cover the spread in each of its last four games.
• Western Kentucky has covered the spread in each of its last four games in Louisiana.

Total Points Facts

• Five of Western Kentucky’s last six games in Louisiana have gone OVER the total points line.
• Five of LSU’s last six games in November have gone UNDER the total points line.

LSU Tigers Player Prop Facts

• Heading into Week 13, Damian Ramos ranks T5th amongst FBS players for made field goals (20) this season.

Western Kentucky Hilltoppers Player Prop Facts

• Heading into Week 13, Cole Maynard ranks 2nd amongst qualified players for gross average yards per punt (48.7) this season.

Matchup/League Facts

• LSU has lost the first quarter in each of its last five games – equal-longest active streak in the FBS.
• LSU ranks T6th among FBS teams for 4th down conversion percentage this season (75.0).
• Western Kentucky ranks 3rd among FBS teams for 4th down conversion percentage against this season (27.3).
• Western Kentucky ranks 6th among FBS teams for Q4 opponent points per game this season (3.2).

Western Kentucky vs LSU Prediction

In this Western Kentucky vs LSU Prediction, LSU is coming as -23.5-point home favorites, with the total set at 50 points. The wrong team is favored in this matchup, as Western Kentucky has more overall wins this season and have been very good on the road. On top of that, they have been in excellent form lately, with a 6-1 record in its last 7 games, while on the other hand LSU is 1-3 in its last 4. Western Kentucky also has a superior offense, scoring 7.7 points per game more than LSU, so the value here lies with the road team. Take Western Kentucky and the +23.5 points in this one.

Nikos Lagouretos's Pick: Western Kentucky +23.5