Oct 17, 2025; Minneapolis, Minnesota, USA; Minnesota Golden Gophers wide receiver Jalen Smith (8) runs after a catch as Nebraska Cornhuskers linebacker Javin Wright (0) defends during the second half at Huntington Bank Stadium. Mandatory Credit: Matt Krohn-Imagn Images
Matt Krohn-Imagn Images

USC vs Nebraska Prediction 11/1/2025 Today’s College Football Picks

Pick details

USC (5-2) vs Nebraska (6-2)

November 1, 2025 at 07:30 PM EDT

The Line: Betting Odds: Nebraska +5.5 — Over/Under: +59.5

(Get latest betting odds)

The USC Trojans and Nebraska Cornhuskers meet Saturday in college football action at Memorial Stadium. Here’s a USC vs Nebraska Prediction. This article will include a USC vs Nebraska Pick.

USC Trojans Betting Preview

The USC Trojans beat Michigan, lost to Notre Dame, and play Northwestern next. The USC Trojans have lost 2 of their last 3 games. Jayden Maiava is completing 68.1 percent of his passes for 2,180 yards, 15 touchdowns and 4 interceptions. Makai Lemon and Jacobi Lane have combined for 1,182 receiving yards and 9 touchdowns, while Lake McRee has 16 receptions.

The USC Trojans ground game is averaging 203.9 yards per contest, and Waymond Jordan leads the way with 576 yards and 5 touchdowns. Defensively, USC is allowing 23.1 points and 365 yards per game. Eric Gentry leads the USC Trojans with 48 tackles, Braylan Shelby has 3.5 sacks and Bishop Fitzgerald has 5 interceptions.

Nebraska Cornhuskers Betting Preview

The Nebraska Cornhuskers lost to Minnesota, beat Northwestern, and they play UCLA next. Nebraska has won 7 of its last 9 games. Dylan Raiola is completing 72.8 percent of his passes for 1,909 yards, 17 touchdowns, and 6 interceptions. Nyziah Hunter and Jacory Barney Jr. have combined for 903 receiving yards and 8 touchdowns, while Dane Key has 23 receptions.

The Nebraska Cornhuskers ground game is averaging 128.8 yards per contest, and Emmett Johnson leads the way with 837 yards and 9 touchdowns. Defensively, Nebraska is allowing 19.6 points and 284 yards per game. Javin Wright leads the Nebraska Cornhuskers with 52 tackles, Dasan McCullough has 2 sacks and DeShon Singleton has 2 interceptions.

Why the Nebraska Cornhuskers will win

  • The home team has won six of USC’s last seven games.
  • USC has lost six of its last eight road games against conference opponents.
  • USC has failed to cover the spread in six of its last seven road games against conference opponents.
  • The underdog has covered the spread in four of USC’s last five games.

Why the USC Trojans will win

  • Nebraska has lost each of its last 14 home games against AP-ranked teams.
  • USC has won eight of its last nine games against non-AP-ranked teams.
  • Nebraska has failed to cover the spread in each of its last seven games against AP-ranked teams at Memorial Stadium (Lincoln).

Total Points Facts

  • Eight of Nebraska’s last nine games at Memorial Stadium (Lincoln) have gone OVER the total points line.
  • Each of USC’s last four November games as a favorite have gone UNDER the total points line.

Nebraska Cornhuskers Player Prop Facts

  • Heading into Week 10, Emmett Johnson ranks 8th amongst FBS players for rushing attempts (146) this season.

USC Trojans Player Prop Facts

  • Makai Lemon has recorded 75+ receiving yards in four consecutive games – equal-longest streak in the FBS, heading into Week 10.

Matchup/League Facts

  • Nebraska ranks T9th among FBS teams for Q1 opponent points per game this season (2.0).
  • Nebraska ranks 127th among FBS teams for red zone percentage against this season (93.8).
  • USC ranks 2nd among FBS teams for red zone percentage against this season (54.5).
  • USC ranks 3rd among FBS teams for H2 points per game this season (20.9).

USC vs Nebraska Prediction

USC is probably the more talented team, but the Trojans haven’t played well on the road this season. Also, USC is 2-11 ATS in its last 13 road games as a favorite. Nebraska is having a solid season for the most part with an offense that’s high-flying and one of the more underrated defenses in the country. Nebraska is 11th in total defense and second in passing defense. Nebraska will be up for this game and is breaking out the black uniforms. The atmosphere will be electric. I’ll take a shot with the points in a game the Huskers could win outright.

Randy Chambers's Pick: Nebraska +5.5

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