UConn vs Syracuse Prediction 9/6/2025 Today’s College Football Picks

In this article, we will formulate a UConn vs Syracuse Prediction for this College Football Week 2 game on Saturday, September 6th at the Rice-Eccles Stadium. Let’s take a look at the prediction for this College Football matchup.

Syracuse Orange Preview

The Orange are coming off a 26-45 home defeat by Tennessee in their season opener. Syracuse outgained their opponents by 377-495 yards. They had 23/40 completed passes, 274 passing yards, 103 rushing yards, with turnovers being 1-2. The Orange went 5-14 in third down efficiency and had 4-30 penalties.

Steve Angeli had 23/40 passes, a team-high 274 passing yards and one touchdown but also threw one interception and lost one fumble. Yasin Willis added a team-high 91 rushing yards, while Dan Villari caught 5 passes for 55 yards. Defensively, David Reese had seven total tackles, all of them solo, while Syracuse did not record any sacks. The Orange did not have any interceptions in this game.

Connecticut Huskies Preview

The Huskies are coming off a 59-13 home victory over Central Connecticut in their season opener last week. UConn outgained their opponents by 681-257 yards. They had 27/38 completed passes, 388 passing yards, 293 rushing yards, with both teams being 0-0 in turnovers. The Huskies went 12-16 in third down efficiency and had 8-78 penalties.

Joe Fagnano had 18/25 passes, a team-high 260 passing yards and three touchdowns. Cam Edwards added a team-high 115 rushing yards, while Skyler Bell caught 4 passes for 135 yards. Defensively, Tyquan King had eight total tackles, five of them solo, while Bryun Parham had one sack. The Huskies did not have any interceptions in this game.

Why the Syracuse Orange will win

• Connecticut has lost each of its last 17 road games in September.
• Syracuse has won each of its last six games against non-conference opponents at JMA Wireless Dome.
• Connecticut has failed to cover the spread in seven of its last eight road openers.
• Connecticut has lost the first half in 16 of its last 18 games against opponents from the Atlantic Coast Conference.

Why the Connecticut Huskies will win

• The underdog has won four of Syracuse’s last six games at JMA Wireless Dome.
• The underdog has covered the spread in each of Syracuse’s last seven games at JMA Wireless Dome.
• Syracuse has failed to cover the spread in seven of its last eight games against non-conference opponents.

Total Points Facts

• Each of Syracuse’s last seven games in September have gone UNDER the total points line.
• Each of Connecticut’s last five games against teams from New York have gone OVER the total points line.

Matchup/League Facts

• Syracuse ranks 136th among FBS teams for Q1 opponent points per game this season (17.0).
• Syracuse ranks 136th among FBS teams for average point differential in first quarters this season (-17.0).
• Connecticut ranks T1st among FBS teams for Q4 opponent points per game this season (0.0).
• Connecticut ranks 2nd among FBS teams for yards per game this season (638.0).

UConn vs Syracuse Prediction

Syracuse won their only meetings against UConn last season by 31-24 at home, not covering the spread, as the game went over the point total. Syracuse has won their last five meetings against UConn, but the Huskies are 6-3-1 against the spread in their last 10 meetings. Over is 4-2 in their last 6 meetings.

In this UConn vs Syracuse Prediction, Syracuse is coming in as -7-point home favorites, with the total set at 58.5 points. Both teams are coming off opposite outcomes in their season openers, but the opposition was on a completely different level. The Huskies won an inferior team, but their offense looked great and both teams are coming off high scoring games, with 71 and 72 total points. Their last two meetings between those two teams have gone over the total, and UConn was 7-3-2 to the over last season. I expect another high-scoring affair today, so take the over 58.5 points in this one.