Sep 20, 2025; Oxford, Mississippi, USA; Tulane Green Wave quarterback Brendan Sullivan (6) runs the ball as Mississippi Rebels linebacker Princewill Umanmielen (1) attempts to make the tackle during the fourth quarter at Vaught-Hemingway Stadium. Mandatory Credit: Petre Thomas-Imagn Images

Tulane vs Tulsa Prediction 9/27/2025 Today’s College Football Picks

Pick details

Tulane (0-3) vs Tulsa (2-2)

September 27, 2025 at 04:00 PM EDT

The Line: Betting Odds: Tulsa +15.5 — Over/Under: +51.5

(Get latest betting odds)

Tulane and Tulsa meet Saturday in Week 5 college football action from Champion Stadium. Here’s a Tulane vs Tulsa prediction. We will look at this from a betting perspective and determine the best Tulane Green Wave vs Tulsa Golden Hurricane pick. We will examine:

The Tulane Green Wave’ recent form and player performance

The Tulsa Golden Hurricane’ recent form and player performance

Recent betting trends and streaks involving the Green Wave

Recent betting trends and streaks involving the Golden Hurricane

Recent betting trends in games played between Tulane and Tulsa

A summary that ties it all together and produces a favorable betting outcome for the Tulane vs Tulsa game

How Does Tulane Bounce Back?

Tulane started off the season strong, but they really struggled in the last game against Ole Miss. Tulane scored only 10 points against the Rebels, while the defense gave up 45 points. Jake Retzlaff was a big get this offseason in the transfer portal, but he was awful against Ole Miss. He completed 5 of his 17 passes for 56 yards, but didn’t find the end zone. He did have a big game on the ground rushing eight times for 51 yards, but the lack of any sort of passing really let them down. 

Tulane on the season is averaging 25 points while their defense is giving up 26.5 points per game. The offense is ranked 90th in the league while the defense is ranked 86th. In this game the defense is going to need to be a whole lot better, if they want a chance for their offense to find enough success to come out ahead. 

Why the Tulane Green Wave will win

  • The favorite has won each of the last 10 games between Tulane and Tulsa.
  • Tulsa has lost seven of its last eight home games against conference opponents.
  • Tulsa has failed to cover the spread in 12 of its last 14 September games at Chapman Stadium.
  • Tulane has covered the spread in five of its last six road games against conference opponents.
  • Tulane has won the first half in seven of its last nine games against conference opponents.

Can Tulsa Build on Last Game?


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Tulsa has not had a ton of success this season losing two of the four games, but the last game was an impressive win, and they are going to look to build on that here. Tulsa went on the road to face off against Oklahoma State, and they were able to secure the 19-12 victory. The defense was elite and made life tough, and that was the difference. The offense also could have scored more, and Baylor Haynes and he completed 22 of his 36 passes for 219 yards and a touchdown. They are going to need him to have a huge game here to find success. 

Tulsa on the season is averaging 22.75 points while their defense is giving up 20.5 points per game. The offense is ranked 98th while the defense is ranked 56th. In this game, the defense is going to need to step up in a maor way and the offense is going to need to get out to a fast start. 

Why the Tulsa Golden Hurricane will win

  • Tulsa has covered the spread in three of its last four games as an underdog in Oklahoma.
  • Tulane has failed to cover the spread in three of its last four road games in September.

Tulane vs Tulsa Prediction

Getting this many points with Tulsa is a dang gift. Yes they might have a little letdown, here but they are getting way too many points. The thing that impressed me the most in the last game for Tulsa was their defense, and they are going to step up in a major way again here. Tulsa’s defense is giving up 20.5 points, and they won’t give many more points than that here. I am really concerned with the way Retzlaff looked in the last game and he’s going to really struggle here. Tulsa probably doesn’t win this game, but they are going to keep it close here. Back Tulsa against the spread.

Shane Mickle's Pick: Tulsa +15.5

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