Syracuse vs Notre Dame Prediction 11/22/2025 Today’s College Football Picks

In this article we will formulate a Syracuse vs Notre Dame prediction for this College Football game on Saturday, November 22nd at Notre Dame Stadium in South Bend, Indiana. Let’s take a look at the prediction for this week 13 matchup. 

Syracuse Orange Betting Preview

The Syracuse Orange are 3-7 (1-6) this season after they lost to Miami by a score of 38-10 in their last game. Syracuse trailed 14-0 at halftime and allowed 24 points in the second half, but did score with 21 seconds left for the back door cover. The Orange were out gained by a total of 385-285, went 6-15 on third downs, and lost the turnover battle by a total of 3-0 in the game. Rickie Collins went 12-25 for 85 yards and two interceptions, while Yasin Willis rushed 13 times for 63 yards. Daunte Bacheyie led the receivers with two catches for 22 yards in the loss. The Syracuse defense recorded two sacks and three tackles for loss in the game. 

Prior to that game, Syracuse lost to North Carolina by a score of 27-10 and Georgia Tech by a score of 41-16. The Orange have lost six games in a row and they are currently second to last in the ACC standings. Syracuse has scored 22.3 points per game with 244.7 passing yards and 117.7 rushing yards per game, while they have allowed 31.5 points against per game this season. Rickie Collins has thrown for 1,042 yards, six touchdowns, and 10 interceptions, while Yasin Willis has rushed for 558 yards and four scores on 129 carries this season. 

Notre Dame Fighting Irish Betting Preview

The Note Dame Fighting Irish are 8-2 this year after they defeated Pittsburgh by a score of 37-15 last week. Notre Dame led 21-3 at halftime and scored 16 of the first 22 points in the second half to pull away with the win. The Fighting Irish out gained Pittsburgh by a total of 387-219, went 4-12 on third downs, and lost the turnover battle by a total of 2-1 in the game. CJ Carr went 21-32 for 212 yards, two touchdowns, and two interceptions, while Jeremiyah Love rushed 23 times for 147 yards and one score. Malachi Fields led the receivers with seven catches for 99 yards and two touchdowns in the win. The ND defense recorded four sacks and seven tackles for loss in the game. 

Prior to that game, Notre Dame defeated Navy by a score of 49-10 and Boston College by a score of 25-10. The Fighting Irish have won eight games in a row and they are technically first in the Independent standings. Notre Dame has scored 38.3 points per game with 265.7 passing yards and 192.5 rushing yards per game, while they have allowed 18.4 points against per game this season. CJ Carr has thrown for 2,487 yards, 21 touchdowns, and six interceptions, while Jeremiyah Love has rushed for 1,135 yards and 14 scores on 177 carries this year. 

Why the Notre Dame Fighting Irish will win

• Notre Dame has won each of its last 15 November games at Notre Dame Stadium.
• Syracuse has lost 10 of its last 11 November games against AP-ranked teams.
• Notre Dame has covered the spread in each of its last 11 games against opponents from the Atlantic Coast Conference at Notre Dame Stadium.
• Syracuse has failed to cover the spread in nine of its last 11 road games in November.

Total Points Facts

• Each of Syracuse’s last four games against AP-ranked teams have gone OVER the total points line.
• Five of Notre Dame’s last six November games at Notre Dame Stadium have gone OVER the total points line.

Matchup/League Facts

• Notre Dame ranks 3rd among FBS teams for Q4 opponent points per game this season (2.9).
• Notre Dame ranks 3rd among FBS teams for interceptions this season (17).
• Syracuse ranks 126th among FBS teams for Q3 points per game this season (3.3).
• Syracuse ranks T126th among FBS teams for average point differential in second quarters this season (-5.0).

Syracuse vs Notre Dame Prediction 

Notre Dame comes into this matchup on a lengthy winning streak and they have scored at least 34 points in four of their last five games. The Fighting Irish have also been very strong on defense, as they have allowed 15 points or fewer in four of their last five. Syracuse has lost six games in a row and their offense has been a mess since their starting quarterback got hurt. The Orange have scored 18 points or fewer in five straight and their defense is allowing a ton of points. This is a very big number to cover at this point in the season, but I have to side with Notre Dame and their high scoring offense.

David Racey is 128-108 (54%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!

David Racey's Pick: Notre Dame -35.5