Nov 30, 2024; Blacksburg, Virginia, USA; Virginia Cavaliers wide receiver Trell Harris (11) is tackled by Virginia Tech Hokies cornerback Mansoor Delane (4) and linebacker Keonta Jenkins (7) during the fourth quarter at Lane Stadium. Mandatory Credit: Peter Casey-Imagn Images

Stanford vs Virginia Prediction 9/20/2025 Today’s College Football Picks

Pick details

Stanford (1-2) vs Virginia (2-1)

September 20, 2025 at 07:30 PM EDT

The Line: Betting Odds: Virginia -15 — Over/Under: +49.5

(Get latest betting odds)

The Stanford Cardinal and Virginia Cavaliers meet Saturday in college football action at Scott Stadium. Here’s a Stanford vs Virginia Prediction. This article will include a Stanford vs Virginia Pick.

Stanford Cardinal Betting Preview


The Stanford Cardinal lost to BYU, beat Boston College, and they play San Jose State next. Stanford has lost 10 of its last 12 games. Ben Gulbranson is completing 53.6 percent of his passes for 437 yards, 1 touchdown, and 3 interceptions. Bryce Farrell and Sam Roush have combined for 227 receiving yards and 1 touchdown, while Caden High has 7 receptions.

The Stanford Cardinal ground game is averaging 136.3 yards per contest, and Micah Ford leads the way with 291 yards and 2 touchdowns. Defensively, Stanford is allowing 23.3 points and 342.3 yards per game. Matt Rose leads the Stanford Cardinal with 30 tackles, Clay Patterson has 3 sacks and Collin Wright has 1 interception.

Virginia Cavaliers Betting Preview


The Virginia Cavaliers lost to NC State, beat William & Mary, and played Florida State next. The Virginia Cavaliers have lost 7 of their last 10 games. Chandler Morris is completing 69.7 percent of his passes for 670 yards, 4 touchdowns, and 1 interception. Trell Harris and Cam Ross have combined for 340 receiving yards and 1 touchdown, while Jahmal Edrine has 11 receptions.

The Virginia Cavaliers ground game is averaging 266.7 yards per contest, and J’Mari Taylor leads the way with 213 yards and 6 touchdowns. Defensively, Virginia is allowing 19.3 points and 311 yards per game. Landon Danley leads the Virginia Cavaliers with 18 tackles, Maddox Marcellus has 1 sack and Ethan Minter has 1 interception.

Stanford Cardinal @ Virginia Cavaliers Betting Trends: Week 4


Why the Virginia Cavaliers will win

  • Stanford has lost eight of its last nine road games.
  • The home team has won each of Virginia’s last four games.
  • The home team has covered the spread in each of Stanford’s last four games.
  • Stanford has failed to cover the spread in six of its last seven games as a road underdog.

Why the Stanford Cardinal will win

  • Virginia has lost 11 of its last 13 home games against conference opponents.
  • Virginia has failed to cover the spread in four of its last five September games as a home favorite.
  • Stanford has covered the spread in three of its last four September road games against non-AP-ranked teams.

Total Points Facts

  • Each of Virginia’s last four home games against conference opponents have gone UNDER the total points line.
  • Each of Stanford’s last four road games in September have gone UNDER the total points line.

Virginia Cavaliers Player Prop Facts

  • Heading into Week 4, J’Mari Taylor leads the Atlantic Coast Conference for touchdowns (6) this season.

Stanford Cardinal Player Prop Facts

  • Heading into Week 4, Micah Ford ranks 9th amongst FBS players for rushing attempts (55) this season.

Matchup/League Facts

  • Virginia ranks T6th among FBS teams for H1 points per game this season (31.3).
  • Virginia ranks 8th among FBS teams for Q4 opponent points per game this season (0.7).
  • Stanford ranks 121st among FBS teams for passing yards per game this season (145.7).
  • Stanford ranks T120th among FBS teams for average point differential in second quarters this season (-6.0).

Stanford vs Virginia Prediction

Stanford has fallen off over the years and hasn’t been that inspiring through three games. Stanford hasn’t done much offensively and is 103rd in pass defense. Stanford is no longer the well coached, toughed team that bullies in the trenches. Virginia is quietly a contender in the ACC with an explosive offense and an underrated defense. Virginia has also covered 8 of its last 9 games as a double-digit favorite. Potential look ahead spot for Virginia, with Florida State on deck next week. I still want little to do with Stanford. Give me Virginia in a home blowout.

Randy Chambers's Pick: Virginia -15

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