Southern Mississippi vs Louisiana Tech Prediction 9/20/2025 Today’s College Football Picks

The Southern Miss Golden Eagles and the Louisiana Tech Bulldogs meet in week 4 college football action from Joe Alliet Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Southern Miss Golden Eagles vs. Louisiana Tech Bulldogs prediction.

Southern Miss Golden Eagles Recap

The Southern Miss Golden Eagles come into this game looking to add on to their 38-22 win over App State last time out to sit at 2-1 on the year. After this game, the Golden Eagles will head home for a game against Jacksonville State.

Golden Eagles Win Back-To-Back Games

Braylon Braxton has thrown for 692 yards, 7 touchdowns and 2 interceptions on 68.7% passing while also rushing for 105 yards on 29 carries. Jeffery Pittman has a team-high 126 rushing yards and 2 touchdowns to lead Southern Miss on the ground while Elijah Metcalf has a team-high 10 catches for 124 yards and Tychaun Chapman has 120 receiving yards for Southern Miss this season. Micah Davis also has 3 receiving TDs as well this season for the Golden Eagles. On defense, Chris Jones has a team-high 31 total tackles while J’Mond Tapp has a team-high 3 sacks. As a unit, USM’s defense has combined for 9 sacks and 6 interceptions so far this season.

Louisiana Tech Bulldogs Recap

The Louisiana Tech Bulldogs come into this game looking to add on to their 49-14 win over New Mexico State last time out to sit at 2-1 on the year. After this game, Louisiana Tech will head on the road for a game against UTEP.

Bulldogs Trying To Find Some Consistency

Blake Baker has thrown for 228 yards and 2 touchdowns on 45.8% passing while Trey Kukuk has 224 passing yards and 2 touchdowns with an interception on 70% passing. Clay Thevenin has rushed for 151 yards and a touchdown while the aforementioned Baker has 116 rushing yards with a score and Kukuk’s rushed for 104 yards as well this year. Devin Gandy has a team-high 78 receiving yards and a touchdown while Eli Finley has 8 grabs for 77 yards and Marques Singleton Jr. has a team-high 9 receptions this season. On defense, Kolbe Fields leads the Bulldogs with 29 total tackles while Mekhi Mason has a team-high 3 sacks with his 23 total tackles. As a unit, Louisiana Tech’s defense has combined for 8 sacks and 5 interceptions so far this season.

Southern Miss Golden Eagles @ Louisiana Tech Bulldogs Betting Trends: Week 4

Why the Louisiana Tech Bulldogs will win

• Southern Miss has lost each of its last seven road games.
• The favorite has won 16 of Southern Miss’ last 17 games.
• Louisiana Tech has covered the spread in each of its last seven games against non-AP-ranked teams.
• Southern Miss has failed to cover the spread in five of its last six completed road games.
• Southern Miss has lost the first half in each of its last nine road games against non-conference opponents.

Why the Southern Miss Golden Eagles will win

• Southern Miss has won each of its last three games as an underdog against Louisiana Tech.
• Louisiana Tech has lost five of its last six games against non-conference opponents.
• The underdog has covered the spread in each of the last four games between Southern Miss and Louisiana Tech.
• Louisiana Tech has failed to cover the spread in four of its last five home games against teams from Mississippi.
• Southern Miss has won the first quarter in three of its last four games against opponents from the Conference USA.
• Louisiana Tech has lost the first half in four of its last five games against non-conference opponents.

Total Points Facts

• Nine of Southern Miss’ last 10 road games against opponents from the Conference USA have gone UNDER the total points line.
• Each of Louisiana Tech’s last five home games against teams from Mississippi have gone OVER the total points line.

Louisiana Tech Bulldogs Player Prop Facts

• Heading into Week 4, Mekhi Mason leads the Conference USA for sacks (3.0) this season.

Southern Miss Golden Eagles Player Prop Facts

• Heading into Week 4, Jeffery Pittman ranks T1st amongst qualified players for catch rate (100.0%) this season.

Matchup/League Facts

• Louisiana Tech ranks T6th among FBS teams for interceptions this season (5).
• Louisiana Tech ranks T13th among FBS teams for H2 opponent points per game this season (4.3).
• Southern Miss ranks T2nd among FBS teams for interceptions this season (6).
• Southern Miss ranks T13th among FBS teams for Q4 points per game this season (11.7).

Southern Miss Golden Eagles vs. Louisiana Tech Bulldogs Prediction

I’m on the under in this one. I get the case to be made for both sides in this game, but for me I just think that it’s a story of the defensive units in this one. LA Tech has been able to get pressure on opposing QBs, and I think they’ll make Braxton work here. On the other side, Southern Miss might have one of the best units defensively in the group of five, and I think this could end up being a lower-scoring, first to 28 wins kind of game. Give me the under here.