Southern Miss vs South Alabama Prediction 11/22/2025 Today’s College Football Picks

The Southern Mississippi Golden Eagles and South Alabama Jaguars meet Saturday in college football action at Hancock Whitney Stadium. Here’s a Southern Miss vs South Alabama Prediction. This article will include a Southern Miss vs South Alabama Pick.

Southern Mississippi Golden Eagles Betting Preview

The Southern Mississippi Golden Eagles beat Arkansas State, lost to Texas State, and will play Troy next. Southern Mississippi has won 5 of its last 6 games. Braylon Braxton is completing 67.3 percent of his passes for 2,187 yards, 19 touchdowns, and 5 interceptions. Elijah Metcalf and Tychaun Chapman have combined for 934 receiving yards and 4 touchdowns, while Micah Davis has 26 receptions.

The Southern Mississippi Golden Eagles ground game is averaging 150.8 yards per contest, and Jeffery Pittman leads the way with 548 yards and 7 touchdowns. Defensively, Southern Mississippi is allowing 25.9 points and 395 yards per game. Chris Jones leads the Southern Mississippi Golden Eagles with 106 tackles, J’Mond Tapp has 5.5 sacks and Josh Moten has 5 interceptions.

South Alabama Jaguars Betting Preview

The South Alabama Jaguars lost to Louisiana, beat UL Monroe, and they play Texas State next. South Alabama has lost 7 of its last 9 games. Bishop Davenport is completing 66.8 percent of his passes for 1,826 yards, 12 touchdowns, and 5 interceptions. Devin Voisin and Jeremy Scott have combined for 1,012 receiving yards and 7 touchdowns, while Anthony Eager has 33 receptions.

The South Alabama Jaguars ground game is averaging 194.3 yards per contest, and Kentrel Bullock leads the way with 814 yards and 10 touchdowns. Defensively, South Alabama is allowing 28.1 points and 356.6 yards per game. Darius McKenzie leads the South Alabama Jaguars with 65 tackles, Tyler Thomas has 2 sacks and Nehemiah Chandler has 2 interceptions.

Why the South Alabama Jaguars will win

• The underdog has won each of South Alabama’s last three games at Hancock Whitney Stadium.
• Southern Miss has lost seven of its last eight games in Alabama.
• Southern Miss has failed to cover the spread in seven of its last eight games in November.
• The underdog has covered the spread in six of South Alabama’s last seven games at Hancock Whitney Stadium.

Why the Southern Miss Golden Eagles will win

• South Alabama has lost each of its last six games in Alabama.
• Southern Miss has won five of its last six games.
• South Alabama has failed to cover the spread in each of its last five games against conference opponents at Hancock Whitney Stadium.
• Southern Miss has covered the spread in three of its last four November games as a road favorite.

Total Points Facts

• Seven of South Alabama’s last eight games at Hancock Whitney Stadium have gone OVER the total points line.
• Each of Southern Miss’ last four November games as a favorite against non-AP-ranked teams have gone UNDER the total points line.

South Alabama Jaguars Player Prop Facts

• Heading into Week 13, Kentrel Bullock ranks 14th amongst FBS players for rushing attempts (180) this season.

Southern Miss Golden Eagles Player Prop Facts

• Heading into Week 13, Braylon Braxton has recorded the equal-longest passing touchdown in a single game this season (98 yards vs Louisiana Ragin’ Cajuns, Week 8).

Matchup/League Facts

• South Alabama ranks 119th among FBS teams for Q2 points per game this season (5.1).
• South Alabama ranks T118th among FBS teams for Q1 opponent points per game this season (8.0).
• Southern Miss ranks T115th among FBS teams for Q1 opponent points per game this season (7.8).
• Southern Miss ranks 115th among FBS teams for time of possession per game this season (28:10).

Southern Miss vs South Alabama Prediction

South Alabama is coming off a nice win over UL Monroe, but it has yet to win back-to-back games this season. Southern Miss has simply been the better team this season by a wide margin, and a top-50 scoring offense should have a field day against this South Alabama defense. South Alabama will be up for this one given its senior day for 21 seniors, but it’s going to take more than that to move the needle. Southern Miss has simple been the more impressive team this season and has a chance to win 8 games for the first time since the 2017 season. I’ll lay the points.

Randy Chambers's Pick: Southern Mississippi -1.5