South Florida vs Memphis Prediction 10/25/2025 Today’s College Football Picks

The USF Bulls and the Memphis Tigers meet in week 9 college football action from Simmons Bank Liberty Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a USF Bulls vs. Memphis Tigers prediction.

USF Bulls Recap

The USF Bulls come into this game looking to build on their 48-13 win over FAU last time out to improve to 6-1 this season. After this game, USF will head home for a game against UTSA. 

Bulls Win 4th In A Row

Byrum Brown has thrown for 1,695 yards, 16 touchdowns and 5 interceptions on 63.4% passing while also leading USF in rushing with 475 rushing yards and 6 scores. Sam Franklin has 275 rushing yards and 3 touchdowns and Nykahi Davenport has 236 rushing yards with 3 TDs as well. Alvon Isaac has 225 rushing yards as well while Chas Nimrod has a team-high 23 catches for 466 yards with 3 TDs and Keshaun Singleton has 363 receiving yards with 3 touchdowns as well this season. Jeremiah Koger has 259 receiving yards and 4 TDs while three more Bulls have 100+ receiving yards as well this year. On defense, Jhalyn Shuler has a team-high 61 total tackles including a team-high 30 solo tackles while Mac Harris has 56 total tackles including 5.5 sacks. James Chenault and Jarvis Lee each have a pair of interceptions as well for the Bulls’ defense this season. As a unit, USF has combined for 16 sacks and 10 interceptions so far this season.

Memphis Tigers Recap

The Memphis Tigers come into this game looking to rebound from a 31-24 loss at the hands of UAB last time out to sit at 6-1 this season. After this game, Memphis will head on the road for a game against Rice.

Tigers Looking For Response After First L

Brendon Lewis has thrown for 1,337 yards, 8 touchdowns and 4 interceptions on 69.5% passing while also rushing for 440 yards and 7 TDs. Sutton Smith has 480 rushing yards to lead Memphis in rushing along with 6 TDs while Greg Desrosiers Jr. has 389 rushing yards and 5 TDs. Cortez Braham has 491 receiving yards and 29 catches along with 5 TDs while Jamari Hawkins has 346 receiving yards and 21 grabs and two more Tigers have 100+ receiving yards as well this season. On defense, Drue Watts has a team-high 42 total tackles while Sam Brumfield has a team-high 3.5 sacks. Kamari Wilson and DeMarco Ward each have a pair of interceptions while Memphis’ defense as a whole has combined for 12 sacks and 10 interceptions so far this season.

South Florida Bulls @ Memphis Tigers Betting Trends: Week 9

Why the Memphis Tigers will win

• Memphis has won each of its last 11 games at Simmons Bank Liberty Stadium.
• South Florida has lost 18 of its last 22 road games against conference opponents.
• Memphis has covered the spread in nine of its last 10 games.
• The team ranked 18th in the AP Poll has failed to cover the spread in five of its last six games.
• Memphis has won the first half in five of its last six games against conference opponents.

Why the South Florida Bulls will win

• South Florida has won seven of its last eight games.
• Memphis has lost each of its last six October games as an underdog.
• The road team has covered the spread in each of the last five games between South Florida and Memphis.
• Memphis has failed to cover the spread in each of its last four home games against teams from Florida.

Total Points Facts

• Eleven of South Florida’s last 12 road games against conference opponents have gone OVER the total points line.
• Four of Memphis’ last five games as an underdog have gone OVER the total points line.

Memphis Tigers Player Prop Facts

• Heading into Week 9, Brendon Lewis leads Memphis for touchdowns (7) this season.

South Florida Bulls Player Prop Facts

• Byrum Brown has recorded a 120.0+ passer rating in two consecutive games – equal-longest streak in the FBS.

Matchup/League Facts

• Memphis has recorded the equal-most home wins by a margin of three points or less of any FBS team this season (1).
• Memphis ranks T3rd among FBS teams for average point differential in fourth quarters this season (+7.3).
• South Florida has recorded the equal-most home wins by a margin of 15+ points of any FBS team this season (4).
• South Florida has recorded the equal-most home wins by a margin of 20+ points of any FBS team this season (4).

USF Bulls vs. Memphis Tigers Prediction

I’m on the over here. I know it’s a decent sized total, but USF’s offense has been outstanding for most of the season, especially in conference play, and Memphis needs to show up after putting up an absolute dud against UAB last week. I think this has all of the makings of a heavyweight showdown in the AAC, and I think the over is in line here. Give me the over.