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South Florida vs Florida Prediction 9/6/2025 Today’s College Football Picks
Pick details
South Florida (1-0) vs Florida (1-0)
September 6, 2025 at 04:15 PM EDT
The Line: Betting Odds: Florida -17.5 — Over/Under: +54.5
USF Bulls Recap
The USF Bulls come into this game looking to build on their season-opening 34-7 beatdown win over Boise State last time out to sit at 1-0 on the year. After this game, USF will head on the road for another in-state power conference matchup against Miami.USF Looking For Another Signature Win
Byrum Brown threw for 210 yards on 16 of 24 passing while also rushing for 43 yards and a pair of touchdowns. Alvon Isaac had a team-high 52 rushing yards while Cartevious Norton had a rushing TD as well. Chas Nimrod led the Bulls with 3 grabs for 96 yards while Keshaun Singleton had a team-high 5 catches for 93 yards and a touchdown. On defense, Jhalyn Shuler led the Bulls with 14 total tackles with 5 solo tackles while De’Shawn Rucker added 11 total tackles with a team-high 7 solo tackles. Rico Watson III also added a sack as well for USF in the win.Why the South Florida Bulls will win
- The underdog has won three of Florida’s last four games at Ben Hill Griffin Stadium.
- South Florida has covered the spread in eight of its last nine games against non-conference opponents.
- Florida has failed to cover the spread in each of its last five September games as a home favorite.
Florida Gators Recap
The Florida Gators come into this game looking to build on their 55-0 win over LIU last time out to sit at 1-0 on the year after their opener. After this game, Florida will head on the road for their SEC opener against LSU.ÂGators Looking For Win In Step Up From Opener
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Why the Florida Gators will win
- South Florida has lost each of its last 13 September games against AP-ranked teams.
- Florida has won each of its last 15 September games as a favorite against non-AP-ranked teams.
- Florida has covered the spread in each of its last eight games in Florida.
- South Florida has failed to cover the spread in three of its last four games as an underdog in Florida.
Total Points Facts
- Seven of Florida’s last eight games against non-conference opponents have gone UNDER the total points line.
- Four of South Florida’s last five games have gone OVER the total points line.
USF Bulls vs. Florida Gators Prediction
I’m on USF and the points in this one. I do think Florida wins but I think they could have one eye on the road to LSU next week, and USF always takes these in-state rivalry games seriously as they’re tired of being viewed as little brother in a lot of them. Florida looked good against LIU, but I think USF had one of the most impressive week 1 showings of anyone. I’ll take USF and the points.Chris Ruffolo's Pick: USF +17.5
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