Aug 28, 2025; Tampa, Florida, USA; South Florida Bulls quarterback Byrum Brown (17) throws a pass against the Boise State Broncos in the first quarter at Raymond James Stadium. Mandatory Credit: Nathan Ray Seebeck-Imagn Images

South Florida vs Florida Prediction 9/6/2025 Today’s College Football Picks

Pick details

South Florida (1-0) vs Florida (1-0)

September 6, 2025 at 04:15 PM EDT

The Line: Betting Odds: Florida -17.5 — Over/Under: +54.5

(Get latest betting odds)

The USF Bulls and the Florida Gators meet in week 2 college football action from Ben Hill Griffin Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a USF Bulls vs. Florida Gators prediction.

USF Bulls Recap

The USF Bulls come into this game looking to build on their season-opening 34-7 beatdown win over Boise State last time out to sit at 1-0 on the year. After this game, USF will head on the road for another in-state power conference matchup against Miami.

USF Looking For Another Signature Win

Byrum Brown threw for 210 yards on 16 of 24 passing while also rushing for 43 yards and a pair of touchdowns. Alvon Isaac had a team-high 52 rushing yards while Cartevious Norton had a rushing TD as well. Chas Nimrod led the Bulls with 3 grabs for 96 yards while Keshaun Singleton had a team-high 5 catches for 93 yards and a touchdown. On defense, Jhalyn Shuler led the Bulls with 14 total tackles with 5 solo tackles while De’Shawn Rucker added 11 total tackles with a team-high 7 solo tackles. Rico Watson III also added a sack as well for USF in the win.

Why the South Florida Bulls will win

  • The underdog has won three of Florida’s last four games at Ben Hill Griffin Stadium.
  • South Florida has covered the spread in eight of its last nine games against non-conference opponents.
  • Florida has failed to cover the spread in each of its last five September games as a home favorite.

Florida Gators Recap

The Florida Gators come into this game looking to build on their 55-0 win over LIU last time out to sit at 1-0 on the year after their opener. After this game, Florida will head on the road for their SEC opener against LSU. 

Gators Looking For Win In Step Up From Opener

Tramell Jones Jr. threw for 131 yards and 2 touchdowns on 12 of 18 passing while DJ Lagway threw for 120 yards and 3 TDs on 15 of 18 passing. Jadan Baugh chipped in 9 carries for 104 yards and a touchdown while Vernell Brown III added 3 catches for 79 yards. TJ Abrams had 53 receiving yards while Hayden Hansen, Tony Livingston, Taylor Spierto, J. Michael Sturdivant and Eugene Wilson III all had a touchdown as well in the win. On defense, Myles Graham had a team-high 5 total tackles including 4 solo tackles while Kamran James had 5 total tackles and Jaden Robinson also had 4 solo tackles. 

Why the Florida Gators will win

  • South Florida has lost each of its last 13 September games against AP-ranked teams.
  • Florida has won each of its last 15 September games as a favorite against non-AP-ranked teams.
  • Florida has covered the spread in each of its last eight games in Florida.
  • South Florida has failed to cover the spread in three of its last four games as an underdog in Florida.

Total Points Facts

  • Seven of Florida’s last eight games against non-conference opponents have gone UNDER the total points line.
  • Four of South Florida’s last five games have gone OVER the total points line.

USF Bulls vs. Florida Gators Prediction

I’m on USF and the points in this one. I do think Florida wins but I think they could have one eye on the road to LSU next week, and USF always takes these in-state rivalry games seriously as they’re tired of being viewed as little brother in a lot of them. Florida looked good against LIU, but I think USF had one of the most impressive week 1 showings of anyone. I’ll take USF and the points.

Chris Ruffolo's Pick: USF +17.5

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