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South Carolina vs Missouri Prediction 9/20/2025 Today’s College Football Picks
Pick details
South Carolina (2-1) vs Missouri (3-0)
September 20, 2025 at 07:00 PM EDT
The Line: Betting Odds: Missouri -11.5 — Over/Under:
The South Carolina Gamecocks and the Missouri Tigers meet Saturday in college football action from Faurot Field. Here’s a South Carolina vs Missouri prediction. We will look at this from a betting perspective and determine the best South Carolina vs Missouri pick. We will examine:
The South Carolina Gamecocks recent form and player performance
The Missouri Tigers recent form and player performance
Recent betting trends and streaks involving the South Carolina Gamecocks
Recent betting trends and streaks involving the Missouri Tigers
Recent betting trends in games played between South Carolina and Missouri
A summary that ties it all together and produces a favorable betting outcome for the South Carolina vs Missouri game
The Gamecocks have three games completed so far this year. First came the opener versus Virginia Tech; South Carolina ended up taking that one 24-11 at home. In game two versus South Carolina State, the Gamecocks scored 17 points in the second quarter and 21 more in the third during a 38-10 victory. QB LaNorris Sellers was 11-of-19 for 128 yards and a TD, and Jawarn Howell had seven carries for 30 yards. Vandrevius Jacobs added four catches for 57 yards and a score to lead the receivers in the win.
In their matchup last weekend versus Vanderbilt, South Carolina couldn’t score after a first-quarter touchdown, eventually losing a shocker 31-7. QB Luke Doty was 18-of-27 for 148 yards and an interception, while Rahsul Faison had 15 carries for 74 yards and a touchdown to lead the rush. Leading receiver Nyck Harbor caught four balls for 66 yards in the disappointing result.
Over on the Missouri side, they’ve got three games in the bag as well. In their opener versus Central Arkansas, the Tigers had no issues whatsoever and won the game 61-6. Game two against Kansas was a little too close for comfort but still a win. Missouri coughed up 21 points in the first quarter alone, but eventually steadied the ship on the way to a 42-31 victory. QB Beau Pribula went 30-of-39 for 334 yards and three scores. Jamal Roberts was the team’s top rusher with 143 yards and a TD on 13 carries, and leading receiver Kevin Coleman put up 10 catches for 126 yards and a TD. Brett Norfleet added 76 yards and a couple of TDs as well.
Matched up against Louisiana on Saturday, the Tigers didn’t have too much trouble. Missouri was up 38-10 by the break and scored in every quarter along the way to a 52-10 victory in the end. Pribula was 15-of-22 for 174 yards, two scores and a pick this time, while Ahmad Hardy topped the rush on 250 yards and three scores. Marquise Davis had a nice day as well with his 113 yards and a TD. Coleman logged high honors among receivers with eight grabs for 84 yards total.
Ahmad Hardy has recorded 50+ rushing yards in 12 consecutive games – longest streak in the FBS, heading into Week 4.
Heading into Week 4, Dylan Stewart leads the Southeastern Conference for sacks (3.0) this season.
Missouri has recorded the equal-most home wins by a margin of 40+ points of any FBS team this season (2).
Missouri has won the fourth quarter in each of its last eight games – longest active streak in the FBS.
South Carolina ranks 121st among FBS teams for 3rd down conversion percentage this season (30.6).
South Carolina ranks 118th among FBS teams for yards per game this season (303.0).
I’ll stay with Missouri, even though a lot of the luster has worn off this one following the Gamecocks’ stunning loss last weekend. In any case, the Tigers waltzed right past Louisiana in their last outing, posting 606 yards (427 rushing), 7.0 yards per play, 32 first downs and a very nice 9-of-13 success rate on third downs. The defense gave up just 121 yards on the other side, four first downs and 1-of-11 on third-down tries. It was a one-sided affair in every sense of the phrase.
Missouri will have to take on a bewildered (and probably angry) South Carolina team this weekend. The Gamecocks didn’t help themselves in the loss to Vandy with four turnovers, eight penalties and a 4-of-12 run on third downs. South Carolina is too good of a team not to bounce back after that one, but I don’t think they’ll quite stick with the Tigers.
The South Carolina Gamecocks recent form and player performance
The Missouri Tigers recent form and player performance
Recent betting trends and streaks involving the South Carolina Gamecocks
Recent betting trends and streaks involving the Missouri Tigers
Recent betting trends in games played between South Carolina and Missouri
A summary that ties it all together and produces a favorable betting outcome for the South Carolina vs Missouri game
South Carolina Gamecocks Betting Preview
The Gamecocks have three games completed so far this year. First came the opener versus Virginia Tech; South Carolina ended up taking that one 24-11 at home. In game two versus South Carolina State, the Gamecocks scored 17 points in the second quarter and 21 more in the third during a 38-10 victory. QB LaNorris Sellers was 11-of-19 for 128 yards and a TD, and Jawarn Howell had seven carries for 30 yards. Vandrevius Jacobs added four catches for 57 yards and a score to lead the receivers in the win.
In their matchup last weekend versus Vanderbilt, South Carolina couldn’t score after a first-quarter touchdown, eventually losing a shocker 31-7. QB Luke Doty was 18-of-27 for 148 yards and an interception, while Rahsul Faison had 15 carries for 74 yards and a touchdown to lead the rush. Leading receiver Nyck Harbor caught four balls for 66 yards in the disappointing result.
Missouri Tigers Betting Preview
Over on the Missouri side, they’ve got three games in the bag as well. In their opener versus Central Arkansas, the Tigers had no issues whatsoever and won the game 61-6. Game two against Kansas was a little too close for comfort but still a win. Missouri coughed up 21 points in the first quarter alone, but eventually steadied the ship on the way to a 42-31 victory. QB Beau Pribula went 30-of-39 for 334 yards and three scores. Jamal Roberts was the team’s top rusher with 143 yards and a TD on 13 carries, and leading receiver Kevin Coleman put up 10 catches for 126 yards and a TD. Brett Norfleet added 76 yards and a couple of TDs as well.
Matched up against Louisiana on Saturday, the Tigers didn’t have too much trouble. Missouri was up 38-10 by the break and scored in every quarter along the way to a 52-10 victory in the end. Pribula was 15-of-22 for 174 yards, two scores and a pick this time, while Ahmad Hardy topped the rush on 250 yards and three scores. Marquise Davis had a nice day as well with his 113 yards and a TD. Coleman logged high honors among receivers with eight grabs for 84 yards total.
South Carolina Gamecocks @ Missouri Tigers Betting Trends: Week 4
Missouri Tigers Player Prop Facts
Ahmad Hardy has recorded 50+ rushing yards in 12 consecutive games – longest streak in the FBS, heading into Week 4.
South Carolina Gamecocks Player Prop Facts
Heading into Week 4, Dylan Stewart leads the Southeastern Conference for sacks (3.0) this season.
Matchup/League Facts
Missouri has recorded the equal-most home wins by a margin of 40+ points of any FBS team this season (2).
Missouri has won the fourth quarter in each of its last eight games – longest active streak in the FBS.
South Carolina ranks 121st among FBS teams for 3rd down conversion percentage this season (30.6).
South Carolina ranks 118th among FBS teams for yards per game this season (303.0).
South Carolina vs Missouri Prediction
I’ll stay with Missouri, even though a lot of the luster has worn off this one following the Gamecocks’ stunning loss last weekend. In any case, the Tigers waltzed right past Louisiana in their last outing, posting 606 yards (427 rushing), 7.0 yards per play, 32 first downs and a very nice 9-of-13 success rate on third downs. The defense gave up just 121 yards on the other side, four first downs and 1-of-11 on third-down tries. It was a one-sided affair in every sense of the phrase.
Missouri will have to take on a bewildered (and probably angry) South Carolina team this weekend. The Gamecocks didn’t help themselves in the loss to Vandy with four turnovers, eight penalties and a 4-of-12 run on third downs. South Carolina is too good of a team not to bounce back after that one, but I don’t think they’ll quite stick with the Tigers.
