SMU vs Clemson Prediction 10/18/2025 Today’s College Football Picks

The SMU Mustangs and Clemson Tigers meet Saturday in college football action at Memorial Stadium. Here’s a SMU vs Clemson Prediction. This article will include a SMU vs Clemson Pick.

SMU Mustangs Betting Preview

The SMU Mustangs beat Syracuse and Stanford, and play Wake Forest next. SMU has split its last 8 games. Kevin Jennings is completing 71.7 percent of his passes for 1,658 yards, 15 touchdowns, and 6 interceptions. Romello Brinson and Jalen Cooper have combined for 755 receiving yards and 5 touchdowns, while Jordan Hudson has 15 receptions.

The SMU Mustangs ground game is averaging 127 yards per contest, and T.J. Harden leads the way with 415 yards and 5 touchdowns. Defensively, SMU is allowing 22.3 points and 423.2 yards per game. Isaiah Nwokobia leads the SMU Mustangs with 48 tackles, Cameron Robertson has 4.5 sacks and Ahmaad Moses has 2 interceptions.

Clemson Tigers Betting Preview

The Clemson Tigers beat Boston College and North Carolina, and they play Duke next. Clemson has split its last 10 games. Cade Klubnik is completing 65.8 percent of his passes for 1,530 yards, 11 touchdowns, and 5 interceptions. Bryant Wesco Jr. and T.J. Moore have combined for 820 receiving yards and 7 touchdowns, while Antonio Williams has 17 receptions.

The Clemson Tigers ground game is averaging 130 yards per contest, and Adam Randall leads the way with 404 yards and 4 touchdowns. Defensively, Clemson is allowing 18.5 points and 323.2 yards per game. Ronan Hanafin leads the Clemson Tigers with 39 tackles, Will Heldt has 3.5 sacks and Ricardo Jones has 2 interceptions.

Why the Clemson Tigers will win

• Clemson has won each of its last 23 October games at Memorial Stadium (Clemson).
• SMU has failed to cover the spread in five of its last six games against non-AP-ranked teams.
• Clemson has covered the spread in three of its last four games in October.

Why the SMU Mustangs will win

• SMU has won each of its last nine road games against conference opponents.
• Clemson has lost three of its last four home games.
• Clemson has failed to cover the spread in each of its last seven games at Memorial Stadium (Clemson).
• SMU has covered the spread in five of its last six road games in October.

Total Points Facts

• Seven of SMU’s last eight October games as an underdog have gone UNDER the total points line.
• Six of Clemson’s last eight October games as a home favorite against non-AP-ranked teams have gone OVER the total points line.

Clemson Tigers Player Prop Facts

• Heading into Week 8, Bryant Wesco Jr. leads the Atlantic Coast Conference for receiving touchdowns (6) this season.

SMU Mustangs Player Prop Facts

• Heading into Week 8, T.J. Harden leads SMU for touchdowns (5) this season.

Matchup/League Facts

• Clemson ranks T20th among FBS teams for Q3 opponent points per game this season (2.8).
• Clemson ranks T114th among FBS teams for H2 points per game this season (9.2).
• SMU ranks 3rd among FBS teams for red zone percentage against this season (64.0).
• SMU ranks 5th among FBS teams for interceptions this season (10).

SMU vs Clemson Prediction

I guess all is good with Clemson after beating up on North Carolina and Boston College. Sorry, that doesn’t do anything for me. Clemson is still a bad team with a bad offense and I need to see more before hopping on board. SMU has an above average offense and a bend but don’t break defense that could steal this game outright if the passing game continues to do what it’s done. Clemson is 4-9 ATS in its last 13 games when favorites of 3 or more points. Obviously, Clemson is the more talented squad and should win at home, but I’m just not impressed with this group overall. It’s SMU and the points or pass for me.