Pittsburgh vs Syracuse Prediction 10/18/2025 Today’s College Football Picks

In this article, we will formulate a Pittsburgh vs Syracuse Prediction for this College Football Week 8 game on Saturday, October 18th at the JMA Wireless Dome. Let’s take a look at the prediction for this College Football matchup.

Syracuse Preview

Syracuse has a 3-3-0 record this season and is sitting 10th in the ACC. They are 3-2-1 ATS, 3-3-0 in Over/Under and have a 2-1-0 home record and a 1-1-0 away record. Syracuse is coming off a 18-31 road loss against SMU and will face Georgia Tech, North Carolina and Miami (FL) next.

Offensively, Syracuse averages 29.0 points per game, ranking 69th in the nation, while defensively, they allow 29.8 points per game, which is 113th. Syracuse averages 432.3 total yards per game (320.7 passing and 111.7 rushing), while allowing 448.8 total yards per game (157.7 rushing and 291.2 passing).

Steve Angeli leads Syracuse with 1,317 passing yards with 62.8% completed passes and 10 touchdowns. Yasin Willis leads the team in rushing yards with 337, while Johntay Cook II has a team-high 31 receptions for 390 receiving yards. Defensively, Gary Bryant III has a team-high 36 total tackles (17 of them solo), while Braheem Long Jr. leads the team in sacks, with 2.0, while Davien Kerr has a team-high two interceptions.

Pittsburgh Preview

Pittsburgh has a 4-2-0 record this season and is sitting 5th in the ACC. They are 4-2-0 ATS, 4-2-0 in Over/Under and have a 3-1-0 home record and a 1-1-0 away record. Pitt is coming off a 34-31 road win against Florida State and will face North Carolina State, Stanford and Notre Dame next.

Offensively, Pitt averages 39.8 points per game, ranking 15th in the nation, while defensively, they allow 21.5 points per game, which is 54th. Pitt averages 431.8 total yards per game (309.3 passing and 122.5 rushing), while allowing 312.3 total yards per game (82.2 rushing and 230.2 passing).

Eli Holstein leads Pittsburgh with 1,058 passing yards with 62.7% completed passes and 11 touchdowns. Desmond Reid leads the team in rushing yards with 187, while Raphael Williams has a team-high 24 receptions for 398 receiving yards. Defensively, Rasheem Biles has a team-high 53 total tackles (18 of them solo), while Blaine Spires leads the team in sacks, with 4.5, while Rasheem Biles has a team-high one interception.

Pittsburgh vs Syracuse Prediction

In their previous meeting last season, Pittsburgh won 41-13 at home, and are 8-2 in their last 10 meetings against Syracuse. Both teams are tied 2-2 in their last 4 meetings in Syracuse, and under is 5-1 in their last 6 meetings.  

In this Pitt vs Syracuse Prediction, Pittsburgh is coming as -11-point road favorites, with the total set at 54.5 points. Both teams are on opposite trajectories lately, with Syracuse having back-to-back losses, with their offense struggling mightily, having scored just 21 points combined in those two games. On the flip side, Pitt is coming off two straight wins, and is better both offensively and defensively than Syracuse, winning by an average of 17.3 points per game this season. The value here lies with the road favorite, so take Pittsburgh and lay the -11 points.