Penn State vs Ohio State Prediction 11/1/2025 Today’s College Football Picks

The Penn State Nittany Lions and Ohio State Buckeyes meet Saturday in college football action at Ohio Stadium. Here’s a Penn State vs Ohio State Prediction. This article will include a Penn State vs Ohio State Pick.

Penn State Nittany Lions Betting Preview

The Penn State Nittany Lions lost to Iowa and Northwestern, and they play Indiana next. Penn State has lost 4 straight games. Ethan Grunkemeyer is completing 59 percent of his passes for 198 yards, 1 touchdown, and 2 interceptions. Devonte Ross and Trebor Pena have combined for 476 receiving yards and 4 touchdowns, while Kyron Hudson has 19 receptions.

The Penn State Nittany Lions ground game is averaging 169.6 yards per contest, and Kaytron Allen leads the way with 612 yards and 9 touchdowns. Defensively, Penn State is allowing 19.4 points and 303.7 yards per game. Amare Campbell leads the Penn State Nittany Lions with 51 tackles, Zuriah Fisher has 2 sacks and Alonzo Ford Jr. has 1 interception.

Ohio State Buckeyes Betting Preview

The Ohio State Buckeyes beat Illinois and Wisconsin, and they play Purdue next. The Ohio State Buckeyes have won 11 straight games. Julian Sayin is completing 80 percent of his passes for 1,872 yards, 19 touchdowns, and 3 interceptions. Jeremiah Smith and Carnell Tate have combined for 1,189 receiving yards and 13 touchdowns, while Max Klare has 20 receptions.

The Ohio State Buckeyes ground game is averaging 151.7 yards per contest, and Bo Jackson leads the way with 433 yards and 2 touchdowns. Defensively, Ohio State is allowing 5.9 points and 216.9 yards per game. Arvell Reese leads the Ohio State Buckeyes with 42 tackles, Caden Curry has 7 sacks and Jermaine Mathews Jr. has 1 interception.

Why the Ohio State Buckeyes will win

• Ohio State has won 57 of its last 58 home games against non-AP-ranked teams.
• Penn State has lost each of its last 11 games as an underdog.
• Ohio State has covered the spread in 10 of its last 11 games as a favorite.
• Penn State has failed to cover the spread in nine of its last 10 November games against top-15 AP-ranked teams.

Why the Penn State Nittany Lions will win

• Penn State has won six of its last seven games in November.
• Penn State has covered the spread in three of its last four road games against Ohio State.

Total Points Facts

• Each of Penn State’s last five November games against top-10 AP-ranked teams have gone UNDER the total points line.
• Each of Ohio State’s last five November games as a favorite against non-AP-ranked teams have gone UNDER the total points line.

Ohio State Buckeyes Player Prop Facts

• Arvell Reese has recorded at least one sack in three consecutive games – equal-longest streak in the FBS, heading into Week 10.

Penn State Nittany Lions Player Prop Facts

• Heading into Week 10, Trebor Pena leads Penn State for receptions (23) this season.

Matchup/League Facts

• Ohio State ranks 1st among FBS teams for Q2 opponent points per game this season (1.3).
• Ohio State ranks 1st among FBS teams for Q4 opponent points per game this season (1.9).
• Penn State ranks T8th among FBS teams for H2 points per game this season (19.3).
• Penn State ranks 11th among FBS teams for average point differential in fourth quarters this season (+5.0).

Penn State vs Ohio State Prediction

Penn State obviously has talent, but it has a backup quarterback and a coaching staff learning on the fly. Not ideal when going up against arguably the best team in the country and an elite defense. I’m not sure how Penn State is going to have success moving the ball. Ohio State is 8-3-1 ATS in its last 12 games as a double-digit favorite. In the 5 games this season as a double-digit favorite, Ohio State is winning by an average of 37.4 points. This has a chance to get ugly for Penn State. Give me Ohio State in a blowout home victory.