Penn State vs Clemson Prediction 12/27/2025 Today’s College Football Picks

The Penn State Nittany Lions and Clemson Tigers meet Friday in the college football Pinstripe Bowl at Yankee Stadium. Here’s a Penn State vs Clemson Prediction. This article will include a Penn State vs Clemson Pick.

Penn State Nittany Lions Betting Preview

The Penn State Nittany Lions beat Nebraska and Rutgers. Penn State has won 3 straight games. Ethan Grunkemeyer is completing 69.4 percent of his passes for 1,079 yards, 6 touchdowns, and 4 interceptions. Devonte Ross and Trebor Pena have combined for 869 receiving yards and 6 touchdowns, while Kyron Hudson has 23 receptions.

The Penn State Nittany Lions ground game is averaging 177.5 yards per contest, and Kaytron Allen leads the way with 1,303 yards and 15 touchdowns. Defensively, Penn State is allowing 21.4 points and 334.3 yards per game. Amare Campbell leads the Penn State Nittany Lions with 96 tackles, Dani Dennis-Sutton has 6.5 sacks and Alonzo Ford Jr. has 1 interception.

Clemson Tigers Betting Preview

The Clemson Tigers beat Furman and South Carolina. Clemson has won 4 straight games. Cade Klubnik is completing 66.6 percent of his passes for 2,750 yards, 16 touchdowns, and 6 interceptions. Antonio Williams and T.J. Moore have combined for 1,358 receiving yards and 8 touchdowns, while Bryant Wesco Jr. has 31 receptions.

The Clemson Tigers ground game is averaging 131.3 yards per contest, and Adam Randall leads the way with 779 yards and 9 touchdowns. Defensively, Clemson is allowing 20.4 points and 353.8 yards per game. Sammy Brown leads the Clemson Tigers with 91 tackles, Will Heldt has 7.5 sacks and Ricardo Jones has 6 interceptions.

Why the Clemson Tigers will win

• The favorite has won each of Penn State’s last six games.
• Penn State has lost 20 of its last 22 games as an underdog.
• Clemson has covered the spread in three of its last four games.
• Penn State has failed to cover the spread in three of its last four games at neutral venues.

Why the Penn State Nittany Lions will win

• Penn State has won eight of its last nine games against non-conference opponents.
• Clemson has failed to cover the spread in six of its last seven games against non-conference opponents at neutral venues.
• The underdog has covered the spread in each of Clemson’s last three games.
• Clemson has lost the first half in each of its last three games against non-conference opponents at neutral venues.

Total Points Facts

• Each of Clemson’s last four games as a favorite in New York have gone UNDER the total points line.
• Seven of Penn State’s last nine Bowl games have gone OVER the total points line

Clemson Tigers Player Prop Facts

• Heading into the bowl games, Ricardo Jones ranks T1st in the Atlantic Coast Conference for interceptions (6) this season.

Penn State Nittany Lions Player Prop Facts

• Heading into the bowl games, Kaytron Allen ranks 9th amongst FBS players for rushing yards (1303) this season.

Matchup/League Facts

• Clemson ranks 120th among FBS teams for passing yards allowed per game this season (250.9).
• Clemson ranks T19th among FBS teams for Q4 opponent points per game this season (4.3).
• Penn State ranks 20th among FBS teams for H2 points per game this season (16.3).
• Penn State ranks 21st among FBS teams for passing yards allowed per game this season (183.5).

Penn State vs Clemson Prediction

Penn State and Clemson ended the season on a high note, so neither of these teams have quit. Could be a good one. Clemson is probably the more talented team, but it will be without a few key defenders and wide receiver Antonio Williams. Penn State won’t have a couple of offensive linemen and running back Nicholas Singleton. Still, Penn State seems to be a bit more whole roster wise, and this should be a very pro Nittany Lions crowd with the game in New York. Clemson was inconsistent offensively with a poor rushing attack, and not having one of its best weapons won’t make things better. Clemson is 4-12 ATS in its last 16 games as a favorite. Give me the points with Penn State.

Randy Chambers's Pick: Penn State +2.5