Ole Miss vs Oklahoma Prediction 10/25/2025 Today’s College Football Picks

The Ole Miss Rebels and the Oklahoma Sooners meet in week 9 college football action from Memorial Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Ole Miss Rebels vs. Oklahoma Sooners prediction.

Ole Miss Rebels Recap

The Ole Miss Rebels come into this game looking to bounce back from a 43-35 loss at the hands of Georgia last time out to sit at 6-1 this season. After this game, Ole Miss will head home for a game against South Carolina.

Rebels Take First Loss Of The Season

Trinidad Chambliss has thrown for 1,549 yards, 8 touchdowns and an interception on 62.7% passing while Austin Simmons has 580 passing yards, 4 touchdowns and 4 interceptions on 60.7% passing. Kewan Lacy has a team-high 618 rushing yards and 10 touchdowns while Harrison Wallace III has a team-high 400 receiving yards and 2 touchdowns. Dae’Quan Wright has 19 grabs for 393 yards and 3 touchdowns while Deuce Alexander has 22 catches for 382 yards. De’Zhaun Stribling has 305 receiving yards and 2 TDs while Cayden Lee has 289 receiving yards and 2 touchdowns. On defense, TJ Dottery has a team-high 46 total tackles while Will Echoles and Zxavian Harris each have a team-high 3 sacks. As a unit, Ole Miss has combined for 10 sacks and 3 interceptions so far this season.

Oklahoma Sooners Recap

The Oklahoma Sooners come into this game looking to add on to their 26-7 win over South Carolina from their last game, improving to 6-1 on the year as a result. After this game, Oklahoma will head on the road for a game against Tennessee.

Sooners Looking To Build Momentum

John Mateer has thrown for 1,567 yards, 7 touchdowns and 6 interceptions on 64.9% passing while also rushing for 209 yards and 5 touchdowns and Tory Blaylock also has a team-high 391 rushing yards and 4 TDs as well this season. Isaiah Sategna III has a team-high 37 receptions for 493 yards and 4 TDs while Jaren Kanak has 364 receiving yards. Deion Burks has 358 receiving yards and Keontez Lewis has 226 receiving yards as well this season. On defense, Kip Lewis has a team-high 31 total tackles while R Mason Thomas has a team-high 5.5 sacks and Taylor Wein has 3.5 sacks. Jayden Jackson has 3 sacks as well for Oklahoma this season. As a unit, Oklahoma has combined for 28 sacks and 3 interceptions this season. 

Ole Miss Rebels @ Oklahoma Sooners Betting Trends: Week 9

Why the Oklahoma Sooners will win

• Oklahoma has won each of its last 14 games as a favorite against top-15 AP-ranked teams.
• Ole Miss has lost each of its last nine October road games against AP-ranked teams.
• Ole Miss has failed to cover the spread in each of its last six October games against AP-ranked teams.
• Oklahoma has covered the spread in each of its last five games as a favorite against top-15 AP-ranked teams.
• Oklahoma has won the first half in 25 of its last 32 games against conference opponents at Oklahoma Memorial Stadium.

Why the Ole Miss Rebels will win

• Ole Miss has won eight of its last nine games.
• Oklahoma has failed to cover the spread in each of its last four October games at Oklahoma Memorial Stadium.
• Ole Miss has won the first half in seven of its last eight games against conference opponents.

Total Points Facts

• Each of Oklahoma’s last eight games have gone UNDER the total points line.
• Seven of Ole Miss’ last eight games in October have gone UNDER the total points line.

Oklahoma Sooners Player Prop Facts

• Heading into Week 9, John Mateer leads Oklahoma for touchdowns (5) this season.

Ole Miss Rebels Player Prop Facts

• Heading into Week 9, Dae’Quan Wright leads the Southeastern Conference for yards per reception (20.7) this season.

Matchup/League Facts

• Oklahoma ranks T1st among FBS teams for Q1 opponent points per game this season (0.4).
• Oklahoma ranks 1st among FBS teams for yards allowed per game this season (213.0).
• Ole Miss has recorded the equal-most home wins by a margin of 10 points or less of any FBS team this season (3).
• Ole Miss has recorded the equal-most home wins by a margin of five points or less of any FBS team this season (2).

Ole Miss Rebels vs. Oklahoma Sooners Prediction

I’m on the under in this one. I think this is going to be a bit of a slugfest and I think Oklahoma’s defense is going to be the unit with the biggest advantage in this game. I just still have a lot of questions about the quarterback play of the Rebels whether it’s Chambliss or Simmons. I think Oklahoma gets after whoever it is, and the Sooners do enough to win this game something along the lines of 27-20. Give me the under here.

Chris Ruffolo's Pick: Under 52.5