Old Dominion vs South Florida Prediction 12/17/2025 Today’s College Football Picks

The Old Dominion Monarchs and the USF Bulls meet in the Cure Bowl in college football action from Camping World Stadium on Wednesday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Old Dominion Monarchs vs. USF Bulls prediction.

Old Dominion Monarchs Recap

The Old Dominion Monarchs come into this game with a record of 9-3 this season including 6-2 in Sun Belt conference play.

Monarchs Looking For First Bowl Win Since 2016

Colton Joseph’s thrown for 2,624 yards, 21 touchdowns and 10 interceptions on 59.7% passing while also posting 1,007 rushing yards and 13 touchdowns and Trequan Jones has 736 rushing yards with 5 scores as well this season. Devin Roche also has 530 rushing yards and 4 TDs. Tre’ Brown III has a team-high 751 receiving yards and 4 TDs while Na’eem Abdul-Rahim Gladding has a team-high 45 catches for 607 yards and 6 TDs. Ja’Cory Thomas also has 38 catches for 674 yards and 5 touchdowns as well this season. On defense, Jerome Carter has a team-high 72 total tackles including 33 solo tackles along with 4 interceptions while Jeremy Mack Jr. has a team-high 4.5 sacks. As a unit, Old Dominion has combined for 35 sacks and 11 interceptions as a unit this season. 

USF Bulls Recap

The USF Bulls come into this game with a record of 9-3 this season, including a 6-2 mark in American Conference Play.

Bulls Looking For Third Straight Bowl Win

Byrum Brown has thrown for 3,158 yards, 28 touchdowns and 7 interceptions on 66.3% passing while also leading USF in rushing with 1,008 rushing yards and 14 scores. Sam Franklin has 445 rushing yards and 4 touchdowns and Nykahi Davenport has 603 rushing yards with 7 TDs as well. Alvon Isaac has 309 rushing yards as well while Keshaun Singleton has a team-high 50 receptions for 877 yards and 8 touchdowns. Jeremiah Koger has 34 grabs for 529 yards with 7 TDs and Chas Nimrod has 23 catches for 466 yards and 3 scores. Mudia Reuben also has 36 grabs for 495 yards and 5 touchdowns. On defense, Mac Harris has a team-high 100 total tackles and a team-high 6 sacks. James Chenault and Jarvis Lee each have a pair of interceptions as well for the Bulls’ defense this season. As a unit, USF has combined for 29 sacks and 14 interceptions so far this season.

Old Dominion Monarchs @ South Florida Bulls Betting Trends: Bowl

Why the South Florida Bulls will win

• South Florida has won each of its last 11 games as a favorite in Florida.
• Old Dominion has failed to cover the spread in each of its last four games against opponents from the American Conference.
• South Florida has covered the spread in six of its last seven games as a favorite in Florida.

Why the Old Dominion Monarchs will win

• Old Dominion has won each of its last five games.
• Old Dominion has covered the spread in four of its last five games against non-conference opponents.
• Old Dominion has won the first half in four of its last five games against non-conference opponents.

Total Points Facts

• Each of Old Dominion’s last five games have gone UNDER the total points line.
• Five of South Florida’s last six games in December have gone OVER the total points line.

South Florida Bulls Player Prop Facts

• Byrum Brown has recorded a 110.0+ passer rating in four consecutive games (including postseason) – equal-longest streak in the FBS.

Old Dominion Monarchs Player Prop Facts

• Heading into the bowl games, Colton Joseph has recorded the equal-longest passing touchdown in a single game this season (98 yards vs James Madison Dukes, Week 8).

Matchup/League Facts

• South Florida has recorded the equal-most home wins by a margin of 25+ points of any FBS team this season (6).
• South Florida ranks 1st among FBS teams for H2 points per game this season (22.9).
• Old Dominion ranks 2nd among FBS teams for 4th down conversion percentage against this season (28.6).
• Old Dominion ranks 6th among FBS teams for average point differential in first quarters this season (+6.7).

Old Dominion Monarchs vs. USF Bulls Prediction

I’m on Old Dominion here. Both teams have their starting QBs opting out for this game, but Old Dominion’s backup, Henicle has at least seen game action while Gaston Moore will start for USF and is a walk-on. I also think Old Dominion’s going to be more motivated to get a bowl win for their coach in Ricky Rahne, who has yet to win a bowl game in six seasons at ODU. I think the motivation lies with the Monarchs so give me Old Dominion and the points.

Chris Ruffolo's Pick: Old Dominion +3