Oklahoma vs South Carolina Prediction 10/18/2025 Today’s College Football Picks

In this article we will formulate an Oklahoma vs South Carolina prediction for this College Football game on Saturday, October 18th at Williams-Brice Stadium in Columbia, South Carolina. Let’s take a look at the prediction for this week 8 matchup. 

Oklahoma Sooners Betting Preview

The Oklahoma Sooners are 5-1 (1-1) this year after they lost to Texas by a score of 23-6 in their last game. Oklahoma led 6-0 in the second quarter, but they allowed the last 23 points for the disappointing loss. The Sooners were out gained by a total of 302-258, went 6-17 on third downs, and lost the turnover battle by a margin of 3-0 in the game. John Mateer went 20-38 for 202 yards and three interceptions, while Tory Blaylock rushed 11 times for 33 yards. Deion Burks led the receivers with five receptions for 64 yards in the loss. The OU defense recorded one sack and 12 tackles for loss in the game. 

Oklahoma started the season with five straight wins over Kent State, Auburn, Temple, Michigan, and Illinois State. The Sooners have won five of their first six games and they are currently tied for seventh in the SEC standings. Oklahoma has scored 29.2 points per game with 266.7 passing yards and 122.3 rushing yards per game, while they have allowed 9.8 points against per game this season. John Mateer has thrown for 1,417 yards, six touchdowns, and six interceptions, while Isaiah Sategna III has 30 receptions for 420 yards and three scores this year. 

South Carolina Gamecocks Betting Preview

The South Carolina Gamecocks are 3-3 (1-3) this season after they lost to LSU by a score of 20-10 in their last game. South Carolina trailed 10-7 at halftime, but they tied the game early in the third quarter, before allowing the last 10 points for the loss. The Gamecocks were out gained by a total of 422-317, went 6-16 on third downs, and won the turnover battle by a total of 3-2 in the game. LaNorris Sellers went 15-27 for 124 yards and one interception, while Matt Fuller rushed seven times for 83 yards and one score. Nyck Harbor led the receivers with two catches for 36 yards in the loss. The SC defense recorded zero sacks and four tackles for loss in the game. 

South Carolina has also lost to Missouri and Vanderbilt, while getting wins against Kentucky, South Carolina State, and Virginia Tech. The Gamecocks have lost three of their last four games and they are currently towards the bottom of the SEC standings. South Carolina has scored 22.3 points per game with 194.7 passing yards and 115.3 rushing yards per game, while they have allowed 19.0 points against per game this season. LaNorris Sellers has thrown for 1,010 yards, four touchdowns, and two interceptions, while Vandrevius Jacobs has 20 receptions for 341 yards and two scores this season. 

Why the South Carolina Gamecocks will win

South Carolina has won five of its last six games at Williams-Brice Stadium.
Oklahoma has lost six of its last eight games against conference opponents.
Oklahoma has failed to cover the spread in each of its last five October games against non-AP-ranked teams.
South Carolina has covered the spread in four of its last five games as an underdog against AP-ranked teams.

Total Points Facts

Eight of Oklahoma’s last nine games have gone UNDER the total points line.
Four of South Carolina’s last five October games as an underdog have gone UNDER the total points line.

Matchup/League Facts

South Carolina ranks 123rd among FBS teams for yards per game this season (310.0).
South Carolina ranks 122nd among FBS teams for time of possession per game this season (27:08).
Oklahoma ranks T1st among FBS teams for red zone percentage this season (100.0).
Oklahoma ranks 2nd among FBS teams for points allowed per game this season (9.8).

Oklahoma vs South Carolina Prediction 

Oklahoma had a ton of momentum going into last week’s game with Texas, but they only managed six points and lost by 17. The Sooners did have Mateer at quarterback, but he was clearly not 100% after missing a few weeks. South Carolina has also had offensive issues over the last month and only scored 10 points against LSU last week. We know Oklahoma’s defense is very good, but I think this is a great spot for South Carolina to come out strong and pick up a huge victory. Take the Gamecocks and the points at home.

David Racey is 70-48 (59%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!