Notre Dame vs Pittsburgh Prediction 11/15/2025 Today’s College Football Picks

The Notre Dame Fighting Irish and Pittsburgh Panthers meet Saturday in college football action at Acrisure Stadium. Here’s a Notre Dame vs Pittsburgh Prediction. This article will include a Notre Dame vs Pittsburgh Pick.

Notre Dame Fighting Irish Betting Preview

The Notre Dame Fighting Irish beat Boston College and Navy, and play Syracuse next. The Notre Dame Fighting Irish have won 7 straight games. CJ Carr is completing 67.6 percent of his passes for 2,275 yards, 19 touchdowns, and 4 interceptions. Jordan Faison and Malachi Fields have combined for 1,042 receiving yards and 6 touchdowns, while Eli Raridon has 24 receptions.

The Notre Dame Fighting Irish ground game is averaging 194.4 yards per contest, and Jeremiyah Love leads the way with 988 yards and 13 touchdowns. Defensively, Notre Dame is allowing 18.8 points and 334.9 yards per game. Drayk Bowen leads the Notre Dame Fighting Irish with 55 tackles, Boubacar Traore has 6.5 sacks and Leonard Moore has 3 interceptions.

Pittsburgh Panthers Betting Preview

The Pittsburgh Panthers beat NC State and Stanford, and they play Georgia Tech next. Pittsburgh has won 5 straight games. Mason Heintschel is completing 64.1 percent of his passes for 1,547 yards, 12 touchdowns, and 5 interceptions. Raphael Williams Jr. and Kenny Johnson have combined for 1,098 receiving yards and 10 touchdowns, while Cataurus Hicks has 19 receptions.

The Pittsburgh Panthers ground game is averaging 124.4 yards per contest, and Ja’Kyrian Turner leads the way with 399 yards and 6 touchdowns. Defensively, Pittsburgh is allowing 21.8 points and 318.3 yards per game. Braylan Lovelace leads the Pittsburgh Panthers with 55 tackles, Jimmy Scott has 4 sacks and Kyle Louis has 2 interceptions.

Why the Pittsburgh Panthers will win

• Pittsburgh has won seven of its last eight games against non-conference opponents at Acrisure Stadium.
• Pittsburgh has covered the spread in each of its last five home games against non-conference opponents.
• Notre Dame has failed to cover the spread in four of its last five road games against opponents from the Atlantic Coast Conference.

Why the Notre Dame Fighting Irish will win

• Notre Dame has won 27 of its last 29 games in November.
• Pittsburgh has lost six of its last seven games in November.
• Notre Dame has covered the spread in seven of its last eight November games as a favorite.
• The team ranked 23rd in the AP Poll has failed to cover the spread in five of its last six games.

Total Points Facts

• Each of Pittsburgh’s last eight games against non-conference opponents at Acrisure Stadium have gone OVER the total points line.
• Ten of Notre Dame’s last 12 November games as a favorite have gone OVER the total points line.

Pittsburgh Panthers Player Prop Facts

• Heading into Week 12, Raphael Williams Jr. ranks T1st in the Atlantic Coast Conference for receiving touchdowns (6) this season.

Notre Dame Fighting Irish Player Prop Facts

• CJ Carr has recorded a 120.0+ passer rating in two consecutive games – equal-longest streak in the FBS.

Matchup/League Facts

• Pittsburgh ranks T5th among FBS teams for average point differential in third quarters this season (+7.2).
• Pittsburgh ranks 6th among FBS teams for points per game this season (39.7).
• Notre Dame ranks 3rd among FBS teams for Q4 opponent points per game this season (2.6).
• Notre Dame ranks T3rd among FBS teams for interceptions this season (16).

Notre Dame vs Pittsburgh Prediction

Notre Dame is the more talented team and should be favored, but this is too much respect. Pittsburgh has one of the best offenses in the country that’s sixth in scoring, and the defense stops the run and is 23rd in total defense overall. Pitt doesn’t get the national love that Notre Dame gets, but this is a good team. Also, Pitt has covered its last 3 games as a double-digit underdog, and that includes an outright win this year over Florida State. Pitt is 7-2 ATS on the season. I wouldn’t be shocked if Notre Dame loses this game outright. Give me the points.

Randy Chambers's Pick: Pittsburgh +12.5