Missouri vs Oklahoma Prediction 11/22/2025 Today’s College Football Picks

The Missouri Tigers and Oklahoma Sooners meet Saturday in college football action at Memorial Stadium. Here’s a Missouri vs Oklahoma Prediction. This article will include a Missouri vs Oklahoma Pick.

Missouri Tigers Betting Preview

The Missouri Tigers lost to Texas A&M, beat Mississippi State, and they play Arkansas next. The Missouri Tigers have split their last 6 games. Beau Pribula is completing 69.6 percent of his passes for 1,685 yards, 11 touchdowns, and 7 interceptions. Marquis Johnson and Kevin Coleman Jr. have combined for 940 receiving yards and 3 touchdowns, while Donovan Olugbode has 22 receptions.

The Missouri Tigers ground game is averaging 241.7 yards per contest, and Ahmad Hardy leads the way with 1,346 yards and 15 touchdowns. Defensively, Missouri is allowing 19.9 points and 277.5 yards per game. Josiah Trotter leads the Missouri Tigers with 61 tackles, Damon Wilson II has 7 sacks and Toriano Pride Jr. has 2 interceptions.

Oklahoma Sooners Betting Preview

The Oklahoma Sooners beat Tennessee and Alabama, and play LSU next. Oklahoma has won 10 of its last 5 games. John Mateer is completing 63.9 percent of his passes for 2,087 yards, 8 touchdowns, and 7 interceptions. Isaiah Sategna III and Deion Burks have combined for 1,172 receiving yards and 7 touchdowns, while Jaren Kanak has 32 receptions.

The Oklahoma Sooners ground game is averaging 130.7 yards per contest, and Tory Blaylock leads the way with 402 yards and 4 touchdowns. Defensively, Oklahoma is allowing 14.8 points and 278.4 yards per game. Kip Lewis leads the Oklahoma Sooners with 60 tackles, R Mason Thomas has 6.5 sacks and Taylor Wein has 1 interception.

Why the Oklahoma Sooners will win

• Oklahoma has won 18 of its last 19 November games at Oklahoma Memorial Stadium.
• Missouri has lost each of its last six November road games against AP-ranked teams.
• Oklahoma has covered the spread in eight of its last nine November games at Oklahoma Memorial Stadium.
• Missouri has failed to cover the spread in each of its last four games against top-15 AP-ranked teams.

Why the Missouri Tigers will win

• The road team has won each of Oklahoma’s last four games.
• Missouri has covered the spread in each of its last four road games in November.

Total Points Facts

• Each of Oklahoma’s last six November games as a home favorite against AP-ranked teams have gone UNDER the total points line.
• Four of Missouri’s last five road games in November have gone OVER the total points line.

Oklahoma Sooners Player Prop Facts

• Heading into Week 13, Tate Sandell ranks T1st in the Southeastern Conference for made field goals (21) this season.

Missouri Tigers Player Prop Facts

• Ahmad Hardy has recorded 50+ rushing yards in 19 consecutive games – longest streak in the FBS, heading into Week 13.

Matchup/League Facts

• Oklahoma ranks 8th among FBS teams for points allowed per game this season (14.8).
• Oklahoma ranks T8th among FBS teams for Q1 opponent points per game this season (2.3).
• Missouri ranks 6th among FBS teams for rushing yards per game this season (241.7).
• Missouri ranks T6th among FBS teams for 4th down conversion percentage this season (75.0).

Missouri vs Oklahoma Prediction

I originally was leaning toward Missouri and the points, especially with us getting a hook on top of a key number. However, Missouri has come up small in every big game this season and is 0-3 SU and 0-2-1 ATS as an underdog this season. Missouri has lost those games by an average of 10.3 points. Oklahoma is coming off monster road wins over Tennessee and Alabama, which are signs this team has figured things out and ready to make a playoff push. Oklahoma is 11-5 ATS in its last 16 games as a home favorite. Oklahoma is 7-4 ATS in its last 11 games when favorites of 5 or more points. I’ll lay the number with Oklahoma at home.

Randy Chambers's Pick: Oklahoma -7.5