Middle Tennessee running back Jekail Middlebrook (9) deflects a tackle from Marshall linebacker Javae Gilmore (9) during MTSU's Homecoming football game on Saturday, Sept. 20, 2025.
HELEN COMER/The Daily News Journal / USA TODAY NETWORK via Imagn Images

Missouri State vs Middle Tennessee Prediction 10/8/2025 Today’s College Football Picks

Pick details

Missouri State (2-3) vs Middle Tennessee (1-4)

October 8, 2025 at 07:30 PM EDT

The Line: Betting Odds: Middle Tennessee +2.5 — Over/Under: +51.5

(Get latest betting odds)

The Missouri State Bears and Middle Tennessee Blue Raiders meet Wednesday in college football action at Johnny “Red” Floyd Stadium. Here’s a Missouri State vs Middle Tennessee Prediction. This article will include a Missouri State vs Middle Tennessee Pick.

Missouri State Bears Betting Preview

The Missouri State Bears beat UT Marlin, lost to Western Kentucky, and they play New Mexico State next. Missouri State has lost 5 of its last 7 games. Jacob Clark is completing 65.2 percent of his passes for 1,195 yards, 8 touchdowns, and 6 interceptions. Dash Luke and Jmariyae Robinson have combined for 522 receiving yards and 3 touchdowns, while Ramone Green Jr. has 12 receptions.

The Missouri State Bears ground game is averaging 109.6 yards per contest, and Shomari Lawrence leads the way with 286 yards and 2 touchdowns. Defensively, Missouri State is allowing 31.6 points and 403.2 yards per game. Kanye Young leads the Missouri State Bears with 29 tackles, Mitchell Toney has 2 sacks and J.J. O’Neal has 1 interception.

Middle Tennessee Blue Raiders Betting Preview

The Middle Tennessee Blue Raiders lost to Marshall and Kennesaw State, and they play Delaware next. Middle Tennessee has lost 7 of its last 8 games. Nicholas Vattiato is completing 58.7 percent of his passes for 1,125 yards, 6 touchdowns, and 4 interceptions. Nahzae Cox and Myles Butler have combined for 521 receiving yards and 4 touchdowns, while Cam’ron Lacy has 13 receptions.

The Middle Tennessee Blue Raiders ground game is averaging 82.2 yards per contest, and Jekail Middlebrook leads the way with 340 yards and 2 touchdowns. Defensively, Middle Tennessee is allowing 31 points and 386.2 yards per game. Parker Hughes leads the Middle Tennessee Blue Raiders with 42 tackles, Zeion Simpson-Smith has 2 sacks and Juwon Gaston has 2 interceptions.

Middle Tennessee Blue Raiders Player Prop Facts

  • Heading into Week 7, Nahzae Cox leads the Conference USA for targets (40) this season.
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Missouri State Bears Player Prop Facts

  • Heading into Week 7, Tristian Gardner leads Missouri State for touchdowns (2) this season.

Matchup/League Facts

  • Middle Tennessee ranks 130th among FBS teams for Q1 opponent points per game this season (11.2).
  • Middle Tennessee ranks 130th among FBS teams for 4th down conversion percentage this season (27.3).
  • Missouri State ranks 131st among FBS teams for average point differential in second quarters this season (-6.4).
  • Missouri State ranks T128th among FBS teams for Q4 points per game this season (2.6).

Missouri State vs Middle Tennessee Prediction

These are two dreadful teams on both sides of the ball so it’s not a game I’m looking to spend my Wednesday watching. With that said, Missouri State has shown more signs of life in games it should compete, while Middle Tennessee is 128th in scoring offense, 115th in scoring defense, and has failed to cover 8 of its last 10 games. Middle Tennessee has little to no betting value these days, and I’m going to fade whenever given the chance. We’re not being asked to lay much with Missouri State, a team that beat Marshall as a touchdown dog, and did some things against SMU. Missouri State is the better team, even if that’s not saying much. Give me Missouri State on the road.

Randy Chambers's Pick: Missouri State -2.5

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