Mississippi State vs Missouri Prediction 11/15/2025 Today’s College Football Picks

The Mississippi State Bulldogs and Missouri Tigers meet Saturday in college football action at Memorial Stadium. Here’s a Mississippi State vs Missouri Prediction. This article will include a Mississippi State vs Missouri Pick.

Mississippi State Bulldogs Betting Preview

The Mississippi State Bulldogs lost to Georgia, beat Arkansas, and they play Ole Miss next. Mississippi State has lost 5 of its last 6 games. Blake Shapen is completing 65.2 percent of his passes for 2,234 yards, 15 touchdowns, and 6 interceptions. Brenen Thompson and Anthony Evans III have combined for 1,488 receiving yards and 10 touchdowns, while Seydou Traore has 27 receptions.

The Mississippi State Bulldogs ground game is averaging 156.8 yards per contest, and Fluff Bothwell leads the way with 534 yards and 6 touchdowns. Defensively, Mississippi State is allowing 26.3 points and 388.7 yards per game. Jahron Manning leads the Mississippi State Bulldogs with 70 tackles, Will Whitson has 2 sacks and Brylan Lanier has 3 interceptions.

Missouri Tigers Betting Preview

The Missouri Tigers lost to Vanderbilt and Texas A&M, and they play Oklahoma next. The Missouri Tigers have lost 3 of their last 4 games. Beau Pribula is completing 69.6 percent of his passes for 1,685 yards, 11 touchdowns, and 7 interceptions. Marquis Johnson and Kevin Coleman Jr. have combined for 899 receiving yards and 3 touchdowns, while Donovan Olugbode has 20 receptions.

The Missouri Tigers ground game is averaging 232.3 yards per contest, and Ahmad Hardy leads the way with 1,046 yards and 12 touchdowns. Defensively, Missouri is allowing 19.1 points and 270 yards per game. Josiah Trotter leads the Missouri Tigers with 59 tackles, Damon Wilson II has 6.5 sacks and Dante McClellan has 1 interception.

Why the Missouri Tigers will win

• Missouri has won each of its last 17 games against non-AP-ranked teams at Faurot Field at Memorial Stadium.
• Mississippi State has lost eight of its last nine road games against conference opponents.
• Missouri has covered the spread in six of its last seven November games against non-AP-ranked teams.
• Mississippi State has failed to cover the spread in three of its last four November games as an underdog against non-AP-ranked teams.

Why the Mississippi State Bulldogs will win

• The road team has won each of Mississippi State’s last three games.
• Missouri has lost three of its last four games against conference opponents.
• Mississippi State has covered the spread in eight of its last nine November games as a road underdog.
• Missouri has failed to cover the spread in each of its last four games at Faurot Field at Memorial Stadium.

Total Points Facts

• Each of Mississippi State’s last five November games against non-AP-ranked teams have gone OVER the total points line.
• Six of Missouri’s last seven games in November have gone OVER the total points line.

Missouri Tigers Player Prop Facts

• Heading into Week 12, Ahmad Hardy is the only player in the FBS to record 1,000 rushing yards with less than 200 attempts this season.

Mississippi State Bulldogs Player Prop Facts

• Heading into Week 12, Brenen Thompson ranks T1st in the Southeastern Conference for receiving yards (808) this season.

Matchup/League Facts

• Missouri ranks T7th among FBS teams for 4th down conversion percentage this season (75.0).
• Missouri ranks 8th among FBS teams for rushing yards per game this season (232.3).
• Mississippi State ranks 10th among FBS teams for average point differential in first quarters this season (+6.4).
• Mississippi State ranks 127th among FBS teams for time of possession per game this season (27:17).

Mississippi State vs Missouri Prediction

Missouri is the better, more balanced team, but it’s been shaky over the last month, and that includes scoring 24 or fewer points in each of its last 3 games. Missouri has scored a combined 27 points in its last 2 games. Mississippi State doesn’t play much defense, but it has the offense to give Missouri a scare. Mississippi State is also one of the best cover teams in the country with an 8-2 ATS record. Mississippi State also needs one more win to become bowl eligible, so this is still a big game for the Bulldogs. I’ll take a free touchdown with a team that’s covering numbers left and right.

Randy Chambers's Pick: Mississippi State +7